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L-Prolinamide is an organic compound that is used in a variety of applications. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water. L-Prolinamide is not typically described in terms of strength, as it is not a medication or supplement that is used to treat specific conditions. Instead, L-Prolinamide is used primarily as a chiral building block in the synthesis of pharmaceuticals and other organic compounds.
(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester
1-(4-methoxyphenyl)ethanone
L-prolinamide
| Conditions | Yield |
|---|---|
|
Irradiation; mild conditions;
|
L-proline methyl ester monohydrochloride
L-prolinamide
| Conditions | Yield |
|---|---|
|
With ammonia; In methanol;
|
91% |
|
With ammonia; In methanol; at 0 - 20 ℃; for 15h; Reagent/catalyst; Large scale;
|
85% |
|
With ammonia; In methanol; at -25 ℃; for 96h; Sealed tube;
|
55% |
|
With ammonia; butan-1-ol; at 20 ℃; for 10h;
|
|
|
With ammonia; In methanol; Heating; Large scale;
|
18 kg |
|
With ammonia; at 0 ℃; for 26h; under 2250.23 Torr; Time;
|
15.8 g |
The CAS number of L-Prolinamide is 7531-52-4.
More information of L-Prolinamide 7531-52-4 are:
|
CAS Number |
7531-52-4 |
| European Community (EC) Number | 231-397-0 |
| UNII | VD6PQK9DHG |
| DSSTox Substance ID | DTXSID00226268 |
| Nikkaji Number | J25.973J |
| Wikidata | Q27103084 |
| Metabolomics Workbench ID | 51285 |
| ChEMBL ID | CHEMBL1222059 |
| XLogP3 | -0.9 |
| Complexity | 103 |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) Eye Irrit. 2A (100%) STOT SE 3 (100%) |
Synonyms for L-Prolinamide 7531-52-4:Prolinamide;(2S)-pyrrolidine-2-carboxamide;H-Pro-NH2;(2S)-2,3,4,5-tetrahydropyrrole-2-carboxamide;(S)-Prolinamide;Pro-NH2;Pro- NH2;L-Prolinmide;
The chemical formula of L-Prolinamide is C5H10N2O which containing 5 Carbon atoms,10 Hydrogen atoms,2 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of L-Prolinamide is 114.147.
L-Prolinamide is generally considered safe when used in appropriate doses and under the guidance of a healthcare professional. It is an organic compound that is naturally occurring in the body and is also found in some foods. Some of the key applications of L-Prolinamide include:
Pharmaceuticals: L-Prolinamide is used as a chiral building block in the synthesis of a number of pharmaceuticals, including antihypertensive agents and anti-inflammatory drugs.
Peptide synthesis: L-Prolinamide is also used in peptide synthesis, as it can be incorporated into peptides to increase their stability and bioactivity.
Organocatalysis: L-Prolinamide is used as an organocatalyst in a number of chemical reactions, including aldol reactions and Michael additions.
Asymmetric synthesis: L-Prolinamide is used as a chiral auxiliary in asymmetric synthesis, where it can help to control the stereochemistry of a reaction.
Overall, L-Prolinamide is a versatile compound with a range of applications in the pharmaceutical and chemical industries.
Relevant articles related to L-Prolinamide:
|
Article |
Source |
| Asymmetric Michael Addition of Unactivated Ketones with β‐Nitrostyrenes Mediated by Bifunctional L‐Prolinamide Organocatalysts | D Rani, M Bhargava, J Agarwal - ChemistrySelect, 2020 |
| Cu (II)-L-prolinamide: First catalytic application of metal-amidoamine complex in enantioselective Henry reaction | R Mohanta, G Bez - Catalysis Communications, 2019 |
| Design, Synthesis And Molecular Docking Of L-Prolinamide Containing Thiazolidine-4-One Ring System As (ACE Inhibitors) | MG Mukhlif, AS Hameed, FS Algburi, NATURAL VOLATILES & ESSENTIAL OILS Journal, 2021 |
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