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N,N-dimethylazetidin-3-amine;dihydrochloride has various applications in the pharmaceutical industry, including as a reagent in organic chemistry and as a starting material for the synthesis of various drugs. It has been found to have potential therapeutic applications, including as an antiviral agent and as a treatment for neurological disorders.
IUPAC Name: N,N-dimethylazetidin-3-amine;dihydrochloride
Isomeric SMILES: CN(C)C1CNC1.Cl.Cl
InChIKey: DHXXDTCOJUYKOQ-UHFFFAOYSA-N
InChI: InChI=1S/C5H12N2.2ClH/c1-7(2)5-3-6-4-5;;/h5-6H,3-4H2,1-2H3;2*1H
Last, 11i was synthesized directly from 17 and N,N-dimethylazetidin-3-amine with a nucleophilic substitution, while the pyrrolidine ring of 14k was obtained from 1,4-diiodobutane and 14a.
The present invention relates to 2,3,4,6...
The present invention relates to a 2,4-d...
3-(dimethylamino)-1-(diphenylmethyl)azetidine
3-(dimethylamino)azetidine dihydrochloride
| Conditions | Yield |
|---|---|
|
3-(dimethylamino)-1-(diphenylmethyl)azetidine; With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 18h;
With hydrogenchloride; In ethanol;
|
87% |
|
3-(dimethylamino)-1-(diphenylmethyl)azetidine; With hydrogen; dimethyl amine; palladium(II) hydroxide/carbon; In ethanol; for 18h;
With hydrogenchloride; In ethanol;
|
87% |
|
With hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 18h;
|
87% |
|
With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;
|
|
|
With hydrogenchloride; palladium dihydroxide; hydrogen; Multistep reaction; 1) Et2O, 0 deg C; 2) EtOH, 60psi, r.t.;
|
tert-butyl 3-(dimethylamino)azetidine-1-carboxylate
3-(dimethylamino)azetidine dihydrochloride
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;
|
82% |
|
With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 3h;
|
82% |
3-(dimethylamino)-1-(diphenylmethyl)azetidine
tert-butyl 3-(dimethylamino)azetidine-1-carboxylate
tert-butyl 3-oxoazetidine-1-carboxylate
dimethyl amine
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(1H-indol-3-yl)pyrimidin-2-amine
5-chloro-N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(1H-indol-3-yl)pyrimidin-2-amine
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-amine
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine
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