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Product Details
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Chemical Properties |
white to off-white crystalline powder |
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Uses |
β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A (T774710) and Trapoxin B as histone deacetylase inhibitors. b-Alanine methyl ester hydrochloride is a fatty acid that is found in animal and plant tissues. |
Isomeric SMILES: COC(=O)CCN.Cl
InChIKey: XPGRZDJXVKFLHQ-UHFFFAOYSA-N
InChI: InChI=1S/C4H9NO2.ClH/c1-7-4(6)2-3-5;/h2-3,5H2,1H3;1H
Briefly, a suspension of 2-fluoro-,B-alanine methyl ester hydrochloride (0.5 mmol) in 7 ml of ethyl acetate containing 0.1 ml oftriethylamine was stirred at 25Cfor 30 min, after which cholic …
… protected by conversion into methyl ester II. The reaction was performed in methanol in the presence of thionyl chloride [6]. The amino group of b-alanine methyl ester hydrochloride was …
A new three-residue turn in β peptides n...
methanol
3-amino propanoic acid
methyl 3-aminopropanoate hydrochloride
| Conditions | Yield |
|---|---|
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methanol; With thionyl chloride; for 1h; Cooling with ice;
3-amino propanoic acid; at 20 - 66 ℃; for 6.5h;
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100% |
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With thionyl chloride; for 3h; Reflux;
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100% |
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With thionyl chloride; at 0 - 20 ℃;
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99% |
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With thionyl chloride; at 0 - 20 ℃; for 2h; Cooling with ice;
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98% |
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With chloro-trimethyl-silane; for 6h; Ambient temperature;
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96% |
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With thionyl chloride; Heating;
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96% |
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With chloro-trimethyl-silane; at 20 ℃; for 12h;
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96% |
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With thionyl chloride; at 0 ℃; for 1h;
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91% |
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With acetyl chloride; at 0 ℃; for 3h; Reflux;
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91% |
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With chloro-trimethyl-silane; at 0 - 20 ℃;
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90% |
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With thionyl chloride; at 20 ℃; for 18h;
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89% |
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With thionyl chloride; for 2.5h;
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88% |
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With thionyl chloride; at 0 ℃;
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85% |
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With thionyl chloride; at 0 - 20 ℃;
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78% |
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With thionyl chloride; at 20 ℃; for 16h;
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77% |
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methanol; With thionyl chloride; at 0 ℃; for 0.333333h;
3-amino propanoic acid; at 20 ℃; for 14h;
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62% |
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With hydrogenchloride;
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With hydrogenchloride; for 17h; Heating;
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With hydrogenchloride; at 60 ℃; for 1.5h;
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With thionyl chloride; for 12h; Heating;
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With thionyl chloride;
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With hydrogenchloride;
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With thionyl chloride; at 60 - 70 ℃;
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With thionyl chloride; at 5 ℃; Inert atmosphere; Reflux;
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With thionyl chloride; at 78 ℃;
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With hydrogenchloride; at 20 ℃;
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With thionyl chloride; Inert atmosphere; Reflux;
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methanol; With thionyl chloride; at 0 ℃; for 1h;
3-amino propanoic acid; at 90 ℃; for 15h;
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With hydrogenchloride; at 20 ℃;
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With thionyl chloride; at 0 - 20 ℃; for 16h; Inert atmosphere;
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With thionyl chloride; at 70 ℃; for 16h;
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With thionyl chloride; at 60 ℃; Cooling with ice;
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With thionyl chloride;
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With thionyl chloride; at 40 ℃; for 12h;
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With thionyl chloride;
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With thionyl chloride; for 12h; Reflux;
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With thionyl chloride; for 5h; Inert atmosphere; Reflux;
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methyl 2-cyanoacetate
methyl 3-aminopropanoate hydrochloride
| Conditions | Yield |
|---|---|
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With hydrogen; potassium hydroxide; In methanol; at 30 ℃; for 2h; under 15001.5 Torr;
|
98.6% |
methanol
3-amino propanoic acid
3-(tert-butyloxycarbonylamino)propionic acid
3-<(tert-butoxycarbonyl)amino>propionitrile
3-amino propanoic acid
2-methoxycarbonylethyl isocyanate
N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine methyl ester
N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-β-alanine methyl ester
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