What is the (R)-2-(methoxycarbonylamino)-2-phenylacetic acid?

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid is , while it's Molecular Formula is C10H11NO4.

What is the CAS number for (R)-2-(methoxycarbonylamino)-2-phenylacetic acid?

The CAS number of (R)-2-(methoxycarbonylamino)-2-phenylacetic acid is 50890-96-5.

What is the (R)-2-(methoxycarbonylamino)-2-phenylacetic acid?

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid is , while it's Molecular Formula is C10H11NO4.

What is the CAS number for (R)-2-(methoxycarbonylamino)-2-phenylacetic acid?

The CAS number of (R)-2-(methoxycarbonylamino)-2-phenylacetic acid is 50890-96-5.

Offer High Quality (R)-2-(methoxycarbonylamino)-2-phenylacetic acid 50890-96-5

Product Details

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CasNo： 50890-96-5
Molecular Formula： C10H11NO4
Purity： 99%

Offer High Quality (R)-2-(methoxycarbonylamino)-2-phenylacetic acid 50890-96-5

Molecular Formula:C10H11NO4
Molecular Weight:209.202
Melting Point:120 °C
Boiling Point:391.3±35.0 °C(Predicted)
PKA:3.96±0.10(Predicted)
PSA：75.63000
Density:1.283±0.06 g/cm3(Predicted)
LogP:1.55920

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid (Cas 50890-96-5) Usage

European Community (EC) Number	694-843-7
Uses	(R)-2-(methoxycarbonylamino)-2-phenylacetic acid is used as a chiral building block in organic synthesis and in the preparation of various pharmaceuticals.

IUPAC Name: (2R)-2-(methoxycarbonylamino)-2-phenylacetic acid
Isomeric SMILES: COC(=O)N[C@H](C1=CC=CC=C1)C(=O)O
InChIKey: GOJLQSAREKTKPT-MRVPVSSYSA-N
InChI: InChI=1S/C10H11NO4/c1-15-10(14)11-8(9(12)13)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,11,14)(H,12,13)/t8-/m1/s1

50890-96-5 Relevant articles

Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier

Abadi, Ashraf H.,Abdallah, Mennatallah,Abdel-Halim, Mohammad,Bartenschlager, Ralf,Frakolaki, Efseveia,Hamed, Mostafa M.,Hirsch, Anna K. H.,Katsamakas, Sotirios,Vassilaki, Niki,Zoidis, Grigoris

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, (2021/04/16)

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Novel symmetric molecules, bearing a ben...

Synthesis of (R)-2-(methoxycarbonylamino)-2-phenylacetic acid via asymmetric reduction of the corresponding α-ketoamide with borane-dimethyl sulfide.

C. M. Cloran, P. E. Fanwick, and R. P. Volante

, Tetrahedron: Asymmetry, vol. 9, no. 7, 1998, pp. 1179-1184

This article describes the synthesis of (R)-2-(methoxycarbonylamino)-2-phenylacetic acid using an asymmetric reduction method with borane-dimethyl sulfide. The compound is an important chiral building block in organic synthesis and pharmaceutical development.

50890-96-5 Process route

: 875-74-1
(R)-phenylglycine

: 79-22-1
methyl chloroformate

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

Conditions

Conditions	Yield
With sodium hydroxide; In water; at 0 ℃; for 1.5h;	92%
With sodium hydroxide; In water; at 0 ℃; for 1.33333h;	91%
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 1h; With hydrogenchloride; In water;	91%
With sodium hydroxide; In water; at 0 ℃; for 1h;	91%
With sodium hydroxide; In water; at 0 ℃; for 1h;	91%
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 - 20 ℃; for 1.33h; With hydrogenchloride; In water;	91%
With sodium hydroxide; In water; at 0 ℃; for 1.33333h;	91%
With sodium hydroxide; In water; at 0 ℃; for 1.33333h;	91%
With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;	80%
(R)-phenylglycine; With sodium hydroxide; In water; at 0 ℃; for 0.0833333h; methyl chloroformate; In 1,4-dioxane; water; at 25 - 30 ℃; for 24h;	71%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	67%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	67%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	67%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	67%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	67%
With sodium carbonate; sodium hydroxide; In water; at 20 ℃; for 3.25h; Cooling with ice;	63%
With sodium hydroxide; In water; toluene; at 20 ℃; for 12h; Cooling with ice;	62%
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 1.33333h; With hydrogenchloride; In water;
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; With hydrogenchloride; In water;
(R)-phenylglycine; With lithium hydroxide; In water; at 0 ℃; methyl chloroformate; In water; at 0 ℃; for 2h;
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 1.33333h; With hydrogenchloride; In diethyl ether; water; at 0 ℃;
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 1.33333h; With hydrogenchloride; In water;
(R)-phenylglycine; methyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 1.33333h; With hydrogenchloride; In diethyl ether; water; at 0 ℃;
With LiOH; In water;
With sodium hydroxide; In water; at 0 ℃; for 1.33333h;
With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃;
With sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃;

: 1007877-76-0
(R)-tert-butyl 2-(methoxycarbonylamino)-2-phenylacetate

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

Conditions

Conditions	Yield
With trifluoroacetic acid; In dichloromethane; for 22.1h; Cooling with ice/water;
With trifluoroacetic acid; In dichloromethane; for 22h;
With trifluoroacetic acid; In dichloromethane; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 22h; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 20h; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 22.14h; Cooling with ice/water;
With trifluoroacetic acid; In dichloromethane; for 22h; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 22h; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 22.11h; Cooling with ice;
With trifluoroacetic acid; In dichloromethane; for 22h; Cooling with ice;	5.57 g
With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 22.1167h;
With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 22h;
With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 22.1167h;
With trifluoroacetic acid; In dichloromethane; for 22.1167h; Cooling with ice/water;
With trifluoroacetic acid; In dichloromethane; Cooling with ice-water bath;
With trifluoroacetic acid; In dichloromethane; Cooling with ice;

50890-96-5 Upstream products

1007877-76-0
(R)-tert-butyl 2-(methoxycarbonylamino)-2-phenylacetate
5817-70-9
methyl N-benzylcarbamate
21116-73-4
N-Benzyl-N-trimethylsilyl-carbamidsaeure-methylester
100-46-9
benzylamine

50890-96-5 Downstream products

1007882-33-8
dimethyl (4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl(1S)-1,1-ethanediyl(methylimino)((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate
1007882-36-1
methyl ((1R)-2-((2S)-2-(5-(4'-(2-((1S)-1-(((2R)-2-((methoxy-carbonyl)amino)-2-phenyl-acetyl)(methyl)amino)ethyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenyl-ethyl)carbamate
1228668-83-4
C₄₈H₄₆N₈O₆
1239656-75-7
C₄₆H₄₈N₈O₆

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50890-96-5

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Offer High Quality (R)-2-(methoxycarbonylamino)-2-phenylacetic acid 50890-96-5

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid (Cas 50890-96-5) Usage

50890-96-5 Relevant articles

Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier

Abadi, Ashraf H.,Abdallah, Mennatallah,Abdel-Halim, Mohammad,Bartenschlager, Ralf,Frakolaki, Efseveia,Hamed, Mostafa M.,Hirsch, Anna K. H.,Katsamakas, Sotirios,Vassilaki, Niki,Zoidis, Grigoris

, (2021/12/27)

Design and synthesis of novel symmetric fluorene-2,7-diamine derivatives as potent hepatitis C virus inhibitors

Mousa, Mai H. A.,Ahmed, Nermin S.,Schwedtmann, Kai,Frakolaki, Efseveia,Vassilaki, Niki,Zoidis, Grigoris,Weigand, Jan J.,Abadi, Ashraf H.

, (2021/04/16)

Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates

Abadi, Ashraf H.,Abdel Karim, Shereen E.,Abdel-Halim, Mohammad,Ahmed, Nermin S.,Frakolaki, Efseveia,Vassilaki, Niki,Youssef, Youssef H.,Zoidis, Grigoris

, (2020/07/27)

Synthesis of (R)-2-(methoxycarbonylamino)-2-phenylacetic acid via asymmetric reduction of the corresponding α-ketoamide with borane-dimethyl sulfide.

C. M. Cloran, P. E. Fanwick, and R. P. Volante

, Tetrahedron: Asymmetry, vol. 9, no. 7, 1998, pp. 1179-1184

50890-96-5 Process route

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