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7531-52-4

  • Product NameL-Prolinamide
  • Molecular FormulaC5H10N2O
  • Molecular Weight114.147
  • Purity99%
  • Appearancewhite crystalline powder
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Product Details

Quick Details

  • CasNo： 7531-52-4
  • Molecular Formula： C5H10N2O
  • Appearance： white crystalline powder
  • Purity： 99%

Best Sale, Buy High Quality Pharmaceutical Intermediates L-Prolinamide White Powder In Medicine In Stock, Best Price, Fast Delivery

  • Molecular Formula:C5H10N2O
  • Molecular Weight:114.147
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:0.000923mmHg at 25°C 
  • Melting Point:97-102 °C 
  • Refractive Index:1.4720 (estimate) 
  • Boiling Point:303.6 °C at 760 mmHg 
  • PKA:16.21±0.20(Predicted) 
  • Flash Point:137.4 °C 
  • PSA：55.12000 
  • Density:1.106 g/cm3 
  • LogP:0.25280 

L-Prolinamide(Cas 7531-52-4) Usage

Chemical Properties

Crystalline

Uses

L-prolinamide is an important raw material and intermediate for pharmaceuticals, e.g. for antidiabetic drugs such as vildagliptin and agrochemicals and is also used as an organocatalyst. Combined with the use of L-prolinamide as a highly soluble and biochemically rather inert substance16 for competitive elution, Pro/Ala-rich sequences (PAS) affinity chromatography offers a mild procedure for the rapid and facile isolation of many different PASylated proteins.

Definition

ChEBI: The carboxamide derivative of L-proline.

InChI:InChI=1/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/p+1/t4-/m1/s1

7531-52-4 Relevant articles

Asymmetric catalysis by l-prolinamide based small molecules: synthesis, characterization and first principle studies on their enantioselectivity

Dixita Rani, Mayank Khera, Neetu Goel, Jyoti Agarwal

Asymmetric catalysis by l-prolinamide based small molecules: synthesis, characterization and first principle studies on their enantioselectivity

Considering the green aspects of chemistry in the context of developing eco-friendly catalysts, the small and easily accessible l-prolinamide molecules have been synthesized in high yields without using any complicated chemistry and expensive chemicals.

Enantioselective Biginelli Reaction Catalyzed by (L)‐Prolinamide Containing Imidazolium Ionic Liquid

Deepa, MJ Aalam, S Singh

ChemistrySelect,Volume7, Issue5 February 4, 2022 e202103918

(L)‐Prolinamide containing imidazolium ionic liquids have been synthesized and evaluated as organocatalysts for the asymmetric Biginelli reaction of benzaldehydes, urea, and β‐keto …

Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus

Kuranov,Tsypysheva,Khvostov,Zainullina, Liana F.,Borisevich,Vakhitova, Yu.V.,Luzina,Salakhutdinov

, p. 4402 - 4409 (2018/07/30)

In this study, bornyl- and cytisine-base...

7531-52-4 Process route

(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester
125219-05-8

(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester

1-(4-methoxyphenyl)ethanone
100-06-1

1-(4-methoxyphenyl)ethanone

L-prolinamide
7531-52-4

L-prolinamide

Conditions
Conditions Yield
Irradiation; mild conditions;
 
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

L-prolinamide
7531-52-4

L-prolinamide

Conditions
Conditions Yield
With ammonia; In methanol;
91%
With ammonia; In methanol; at 0 - 20 ℃; for 15h; Reagent/catalyst; Large scale;
85%
With ammonia; In methanol; at -25 ℃; for 96h; Sealed tube;
55%
With ammonia; butan-1-ol; at 20 ℃; for 10h;
 
With ammonia; In methanol; Heating; Large scale;
18 kg
With ammonia; at 0 ℃; for 26h; under 2250.23 Torr; Time;
15.8 g

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