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Product Details
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Chemical Properties |
White powder crystal |
| Use | Fmoc-Glu(OtBu)-OH is the standard Fmoc-protected derivatives of Glu used in peptide synthesis. |
InChI=1S/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1
Then, the protected GGT substrate (Fmoc-Glu-OtBu) was coupled with a self-immolative linker, p-aminobenzyl alcohol (PABA). It was followed by bromination of the hydroxyl group …
Hereafter, the Fmoc-Glu-OtBu and palmitic acid or Fmoc-OEG-OH, Fmoc-Glu-OtBu, and octadecanedioic acid mono-tert-butyl ester were coupled in order according to the structure of …
L-glutamic acid
9-fluorenylmethyl N-succinimidyl carbonate
isobutene
Fmoc-Glu-OtBu
Fmoc-Glu(OtBu)-OH
N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester
| Conditions | Yield |
|---|---|
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With sodium carbonate; toluene-4-sulfonic acid; Yield given. Multistep reaction. Yields of byproduct given; 1) dioxane, gas pressure: 350 mbar, 3 d, r.t., 2) dioxane, 0 deg C to r.t., 14 h;
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(fluorenylmethoxy)carbonyl chloride
L-glutamic acid α-tert-butyl ester
Fmoc-Glu-OtBu
| Conditions | Yield |
|---|---|
|
With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 16h;
|
99% |
L-glutamic acid α-tert-butyl ester
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
L-glutamic acid
9-fluorenylmethyl N-succinimidyl carbonate
(2S)-N2-(9-fluorenylmethyloxycarbonyl)-glutamic acid α-tert-butyl ester γ-N-hydroxysuccinimide ester
2-{4-tert-butoxycarbonyl-2-[4-tert-butoxycarbonyl-2-(4-tert-butoxycarbonyl-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid 5-tert-butyl ester
γ-L-glutamyl-L-glutamic acid
γ-L-glutamyl-γ-L-glutamyl-L-cysteinylglycine
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