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Product Details
Chemical Properties |
White Solid |
Uses |
L-Glutamic Acid α-tert-Butyl Ester is an ester of L-Glutamic Acid used in the synthesis of enantiopure isotopomers of amino acids. |
IUPAC Name: (4S)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
Isomeric SMILES: CC(C)(C)OC(=O)[C@H](CCC(=O)O)N
InChIKey: QVAQMUAKTNUNLN-LURJTMIESA-N
InChI: InChI=1S/C9H17NO4/c1-9(2,3)14-8(13)6(10)4-5-7(11)12/h6H,4-5,10H2,1-3H3,(H,11,12)/t6-/m0/s1
The choice of the experimental conditions (preactivation of Pal-OH and Pal-Glu-OtBu with formation of the respective -OSu active esters) allowed us to use H-Glu-OtBu in the first step …
Boc- L -aspartic acid α-benzyl ester and Boc- L -glutamic acid α-tert-butyl ester derivatives 20 were successfully engaged in this process yielding to chiral unnatural α-amino acids 3 u–3 …
di-tert-butyl L-glutamate
L-glutamic acid
L-glutamic acid 5-tert-butyl ester
L-glutamic acid α-tert-butyl ester
Conditions | Yield |
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With hydrogenchloride; water; sodium acetate; for 20 - 24h; pH=4.7 - 5.0; Conversion of starting material;
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With potassium phosphate; water; at 40 ℃; for 46h; pH=5.5 - 6.5; Conversion of starting material;
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With sulfuric acid; water; sodium acetate; for 20 - 24h; pH=4.8; Conversion of starting material;
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With water; sodium acetate; at 50 ℃; for 43 - 65h; pH=5.0; Conversion of starting material;
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With water; sodium acetate; at 40 ℃; for 46h; pH=5.5; Conversion of starting material;
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With water; sodium acetate; at 40 ℃; for 46h; Conversion of starting material;
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With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium acetate buffer;
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With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium citrate buffer;
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With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium formate buffer;
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With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium succinate buffer;
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With water; at 40 ℃; for 46h; Conversion of starting material;
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L-glutamic acid di-tert-butyl ester hydrochloride
L-glutamic acid
L-glutamic acid 5-tert-butyl ester
L-glutamic acid α-tert-butyl ester
Conditions | Yield |
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With water; sodium acetate; at 50 ℃; for 25h; pH=4.9; Conversion of starting material;
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Glutamic acid
L-glutamic acid di-tert-butyl ester hydrochloride
di-tert-butyl L-glutamate
Bzl-Glu-NTA
Fmoc-Glu-OtBu
α-tert-butyl N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamate
L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester
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