45120-30-7

  • Product NameL-Glutamic acid α-tert·butyl ester
  • Molecular FormulaC9H17NO4
  • Molecular Weight203.238
  • Purity99%
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Product Details

Quick Details

  • CasNo: 45120-30-7
  • Molecular Formula: C9H17NO4
  • Purity: 99%

L-Glutamic acid α-tert·butyl ester 45120-30-7 In Medicine with Wholesale Price

  • Molecular Formula:C9H17NO4
  • Molecular Weight:203.238
  • Melting Point:140 °C 
  • Refractive Index:14 ° (C=1, H2O) 
  • Boiling Point:326.8 °C at 760 mmHg 
  • PKA:4.22±0.10(Predicted) 
  • Flash Point:151.5 °C 
  • PSA:89.62000 
  • Density:1.133 g/cm3 
  • LogP:1.22050 

L-Glutamic acid α-tert·butyl ester(Cas 45120-30-7) Usage

Chemical Properties

White Solid

Uses

L-Glutamic Acid α-tert-Butyl Ester is an ester of L-Glutamic Acid used in the synthesis of enantiopure isotopomers of amino acids.

IUPAC Name: (4S)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid  
Isomeric SMILES: CC(C)(C)OC(=O)[C@H](CCC(=O)O)N  
InChIKey: QVAQMUAKTNUNLN-LURJTMIESA-N  
InChI: InChI=1S/C9H17NO4/c1-9(2,3)14-8(13)6(10)4-5-7(11)12/h6H,4-5,10H2,1-3H3,(H,11,12)/t6-/m0/s1

45120-30-7 Relevant articles

Innovative chemical synthesis and conformational hints on the lipopeptide liraglutide

Ivan Guryanov, Alex Bondesan, Dario Visentini, Andrea Orlandin, Barbara Biondi, Claudio Toniolo, Fernando Formaggio, Antonio Ricci, Jacopo Zanon, Walter Cabri

, Journal of Peptide Science, Volume22, Issue7 July 2016 Pages 471-479

The choice of the experimental conditions (preactivation of Pal-OH and Pal-Glu-OtBu with formation of the respective -OSu active esters) allowed us to use H-Glu-OtBu in the first step …

Electroreductive Cross‐Coupling of Trifluoromethyl Alkenes and Redox Active Esters for the Synthesis of Gem‐Difluoroalkenes

A Claraz, C Allain, G Masson

, Chemistry–A European Journal, 2022

Boc- L -aspartic acid α-benzyl ester and Boc- L -glutamic acid α-tert-butyl ester derivatives 20 were successfully engaged in this process yielding to chiral unnatural α-amino acids 3 u–3 …

45120-30-7 Process route

di-tert-butyl L-glutamate
16874-06-9

di-tert-butyl L-glutamate

L-glutamic acid
56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

L-glutamic acid

L-glutamic acid 5-tert-butyl ester
2419-56-9

L-glutamic acid 5-tert-butyl ester

L-glutamic acid α-tert-butyl ester
45120-30-7

L-glutamic acid α-tert-butyl ester

Conditions
Conditions Yield
With hydrogenchloride; water; sodium acetate; for 20 - 24h; pH=4.7 - 5.0; Conversion of starting material;
 
With potassium phosphate; water; at 40 ℃; for 46h; pH=5.5 - 6.5; Conversion of starting material;
 
With sulfuric acid; water; sodium acetate; for 20 - 24h; pH=4.8; Conversion of starting material;
 
With water; sodium acetate; at 50 ℃; for 43 - 65h; pH=5.0; Conversion of starting material;
 
With water; sodium acetate; at 40 ℃; for 46h; pH=5.5; Conversion of starting material;
 
With water; sodium acetate; at 40 ℃; for 46h; Conversion of starting material;
 
With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium acetate buffer;
 
With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium citrate buffer;
 
With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium formate buffer;
 
With water; for 24h; pH=5.5; Conversion of starting material; Aqueous sodium succinate buffer;
 
With water; at 40 ℃; for 46h; Conversion of starting material;
 
L-glutamic acid di-tert-butyl ester hydrochloride
32677-01-3

L-glutamic acid di-tert-butyl ester hydrochloride

L-glutamic acid
56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

L-glutamic acid

L-glutamic acid 5-tert-butyl ester
2419-56-9

L-glutamic acid 5-tert-butyl ester

L-glutamic acid α-tert-butyl ester
45120-30-7

L-glutamic acid α-tert-butyl ester

Conditions
Conditions Yield
With water; sodium acetate; at 50 ℃; for 25h; pH=4.9; Conversion of starting material;
 

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