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Product Details
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Description |
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and in the synthesis of PROTACs. |
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Uses |
20-(tert-Butoxy)-20-oxoicosanoic acid is a useful research chemical compound which has various potential uses, including: Surface coatings: TOI acid can be used to create coatings that are resistant to water and oil. This makes it useful in the production of paints, coatings, and other surface treatments. Polymer production: TOI acid can be used as a monomer in the production of polymers, such as polyesters and polyamides. These polymers have a range of applications, including in the production of textiles, plastics, and adhesives. Biomedical applications: TOI acid has been studied for its potential use in biomedical applications, such as drug delivery and tissue engineering. It has been shown to have low toxicity and good biocompatibility, making it a promising candidate for these applications. Chemical research: TOI acid is used as a reagent in various chemical reactions, including the synthesis of other compounds. |
IUPAC Name: 20-[(2-methylpropan-2-yl)oxy]-20-oxoicosanoic acid
Isomeric SMILES: CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)O
InChIKey: JUCDAUSILDWYOA-UHFFFAOYSA-N
InChI: InChI=1S/C24H46O4/c1-24(2,3)28-23(27)21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22(25)26/h4-21H2,1-3H3,(H,25,26)
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tert-butyl icosanedioic acid
eicosanedioic acid mono(1,1-dimethylethyl)ester
octadecane-1,18-dicarboxylic acid
20-methoxy-20-oxoicosanoic acid
| Conditions | Yield |
|---|---|
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With methanol; barium hydroxide octahydrate; at 30 - 35 ℃; for 14.5h;
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10-bromodecanoic acid
eicosanedioic acid mono(1,1-dimethylethyl)ester
octadecane-1,18-dicarboxylic acid
20-methoxy-20-oxoicosanoic acid
| Conditions | Yield |
|---|---|
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Multi-step reaction with 3 steps
1.1: trifluoroacetic anhydride / dichloromethane / 0.5 h / 0 °C / Large scale
1.2: 2 h / 0 - 10 °C / Large scale
2.1: zinc; nickel(II) chloride hexahydrate; 2,2':6,2''-terpyridine / N,N-dimethyl-formamide / 10 h / 35 - 45 °C / Inert atmosphere; Large scale
3.1: barium hydroxide octahydrate; methanol / 14.5 h / 30 - 35 °C
With methanol; 2,2':6,2''-terpyridine; nickel(II) chloride hexahydrate; barium hydroxide octahydrate; trifluoroacetic anhydride; zinc; In dichloromethane; N,N-dimethyl-formamide;
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octadecane-1,18-dicarboxylic acid
N,N-dimethylformamide di-tert-butyl acetal
1,20-eicosanedioyl dichloride
di-tert-butyl dicarbonate
20-bromo-icosanoic acid tert-butyl ester
docosanedioic acid mono-tert-butyl ester
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