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Product Details
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Description |
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and in the synthesis of PROTACs. |
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Uses |
20-(tert-Butoxy)-20-oxoicosanoic acid is a useful research chemical compound. |
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tert-butyl icosanedioic acid
eicosanedioic acid mono(1,1-dimethylethyl)ester
octadecane-1,18-dicarboxylic acid
20-methoxy-20-oxoicosanoic acid
| Conditions | Yield |
|---|---|
|
With
methanol; barium hydroxide octahydrate;
at 30 - 35 ℃;
for 14.5h;
|
10-bromodecanoic acid
eicosanedioic acid mono(1,1-dimethylethyl)ester
octadecane-1,18-dicarboxylic acid
20-methoxy-20-oxoicosanoic acid
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1.1: trifluoroacetic anhydride / dichloromethane / 0.5 h / 0 °C / Large scale
1.2: 2 h / 0 - 10 °C / Large scale
2.1: zinc; nickel(II) chloride hexahydrate; 2,2':6,2''-terpyridine / N,N-dimethyl-formamide / 10 h / 35 - 45 °C / Inert atmosphere; Large scale
3.1: barium hydroxide octahydrate; methanol / 14.5 h / 30 - 35 °C
With
methanol; 2,2':6,2''-terpyridine; nickel(II) chloride hexahydrate; barium hydroxide octahydrate; trifluoroacetic anhydride; zinc;
In
dichloromethane; N,N-dimethyl-formamide;
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octadecane-1,18-dicarboxylic acid
N,N-dimethylformamide di-tert-butyl acetal
1,20-eicosanedioyl dichloride
di-tert-butyl dicarbonate
20-bromo-icosanoic acid tert-butyl ester
docosanedioic acid mono-tert-butyl ester
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