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Product Details
| European Community (EC) Number | 682-153-9 |
|
Uses |
(R)-N-BOC-2-methylproline is commonly used as a chiral building block in peptide synthesis. It can be used in the development of drugs that target specific enzymes or receptors in the body. (R)-N-BOC-2-methylproline is used as a reagent in various chemical reactions, including asymmetric synthesis and cross-coupling reactions. |
| DSSTox Substance ID | DTXSID00654643 |
| Complexity | 308 |
IUPAC Name: (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Isomeric SMILES: C[C@@]1(CCCN1C(=O)OC(C)(C)C)C(=O)O
InChIKey: YQXRKJHVAUKXRN-LLVKDONJSA-N
InChI: InChI=1S/C11H19NO4/c1-10(2,3)16-9(15)12-7-5-6-11(12,4)8(13)14/h5-7H2,1-4H3,(H,13,14)/t11-/m1/s1
The present disclosure relates to compou...
(R)-Boc-2-methylproline (3a) was synthes...
The invention discloses a synthetic meth...
(R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate
(R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid
| Conditions | Yield |
|---|---|
|
With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; under 2828.7 Torr; Inert atmosphere;
|
99.3% |
|
With hydrogen; 5%-palladium/activated carbon; In ethanol; Isopropyl acetate; at 40 ℃; under 2068.65 Torr;
|
97% |
di-tert-butyl dicarbonate
(R)-2-Methyl-1-azacyclopentan-2-carbonsaeure
(R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid
| Conditions | Yield |
|---|---|
|
With tetramethyl ammoniumhydroxide; In acetonitrile; at 20 - 40 ℃;
|
93% |
|
With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
|
74% |
|
With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;
|
|
|
With triethylamine; In water; acetonitrile; at 25 ℃; for 10h;
|
(R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate
di-tert-butyl dicarbonate
(R)-2-Methyl-1-azacyclopentan-2-carbonsaeure
(R)-tert-butyl 2-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-ylcarbamoyl)-2-methylpyrrolidine-1-carboxylate
veliparib
tert-butyl (R)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate
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