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Product Details
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Solubility in organics |
Soluble in methanol and ethanol. |
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Uses |
(R)-3-(Boc-amino)piperidine is used as an organic chemical synthesis intermediate. |
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storage |
Stable under recommended storage conditions. Incompatible with oxidizing agents. |
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Chemical Properties |
White powder |
IUPAC Name: tert-butyl N-[(3R)-piperidin-3-yl]carbamate
Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H]1CCCNC1
InChIKey: WUOQXNWMYLFAHT-MRVPVSSYSA-N
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-5-4-6-11-7-8/h8,11H,4-7H2,1-3H3,(H,12,13)/t8-/m1/s1
When (R)-3-Boc-aminopiperidine as starting material with primary amine protected to avoid generating positional isomers impurities. So the synthetic route shown in Fig. 1 was …
The invention relates to a synthesis met...
The invention discloses a preparation me...
During our investigation of the synthetic route for linagliptin via (R)-3-Boc-aminopiperidine, two process-related impurities were detected (Figure 2), which could also be found in …
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
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With palladium 10% on activated carbon; hydrogen; In methanol; water; at 35 - 40 ℃; for 2h; under 2250.23 - 3000.3 Torr; Time; Autoclave; Inert atmosphere;
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95.4% |
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With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 168h; under 760.051 Torr;
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92% |
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In ethanol;
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tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate
(R)-piperidin-3-ylcarbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 - 25 ℃; for 20h; under 150015 Torr;
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97% |
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With palladium 10% on activated carbon; hydrogen; In methanol; at 45 ℃; for 2h; under 1140.08 Torr;
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85% |
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With hydrogen; 10% palladium on activated carbon; In metahnol; at 20 ℃; for 24h;
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(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester
tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate
t-butyl (R)-piperidin-3-ylcarbamate R-mandelate
D-Glutamic acid
[(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester
tert-butyl {(3R)-1-[3-(2-chloro-5-fluorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-2-yl]piperidin-3-yl}carbamate
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-2-yl]piperidin-3-yl}carbamate
R-2-(3-tert-butoxycarbonylamino-piperidin-1-yl)-1-(4-fluoro-benzyl)-1H-benzimidazole-5-carbonic acid methyl ester
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