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147081-29-6

  • Product Name(S)-4-N-Boc-2-methylpiperazine
  • Molecular FormulaC10H20N2O2
  • Molecular Weight200.281
  • Purity99%
  • Appearancecolorless to yellow liquid
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Product Details

Quick Details

  • CasNo： 147081-29-6
  • Molecular Formula： C10H20N2O2
  • Appearance： colorless to yellow liquid
  • Purity： 99%

(S)-4-N-Boc-2-methylpiperazine 147081-29-6 Crystalline Powder In Stock

  • Molecular Formula:C10H20N2O2
  • Molecular Weight:200.281
  • Appearance/Colour:colorless to yellow liquid 
  • Vapor Pressure:0.00755mmHg at 25°C 
  • Melting Point:40-45 °C 
  • Refractive Index:1.459 
  • Boiling Point:268.7 °C at 760 mmHg 
  • PKA:8.52±0.40(Predicted) 
  • Flash Point:116.3 °C 
  • PSA：41.57000 
  • Density:0.997 g/cm3 
  • LogP:1.48190 

(S)-4-N-Boc-2-methylpiperazine(Cas 147081-29-6) Usage

Chemical Properties

colorless to yellow liquid

Uses

(S)-4-N-Boc-2-methylpiperazine is commonly used as Laboratory chemicals, Manufacture of substances.

IUPAC Name: tert-butyl (3S)-3-methylpiperazine-1-carboxylate  
Isomeric SMILES: C[C@H]1CN(CCN1)C(=O)OC(C)(C)C  
InChIKey: FMLPQHJYUZTHQS-QMMMGPOBSA-N  
InChI: InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1  

147081-29-6 Relevant articles

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

-

Paragraph 00293; 00351, (2019/07/13)

The present application relates to compo...

Solvent-free mechanochemical grinding facilitates clean synthesis of N-substituted amines

Neha Sharma,a   Himanshi Sharma,a   Manoj Kumar,a   Maria Grishina,b   Unnat Pandit,c   Poonam  d  and  Brijesh Rathi *a

, Organic & Biomolecular Chemistry, Issue 33, 2022

N-Protected piperazine with labile functional groups ie, tert-butyl piperazine-1-carboxylate 2k, tert-butyl 3-methylpiperazine-1-carboxylate 2l and 1-(methylsulfonyl)piperazine 2m …

Development of an Efficient Manufacturing Process for Reversible Bruton's Tyrosine Kinase Inhibitor GDC-0853

Zhang, Haiming,Cravillion, Theresa,Lim, Ngiap-Kie,Tian, Qingping,Beaudry, Danial,Defreese, Jessica L.,Fettes, Alec,James, Philippe,Linder, David,Malhotra, Sushant,Han, Chong,Angelaud, Remy,Gosselin, Francis

, p. 978 - 990 (2018/07/15)

Efforts toward the process development o...

High‐Tc Enantiomeric Ferroelectrics Based on Homochiral Dabco‐derivatives (Dabco=1,4‐Diazabicyclo[2.2.2]octane)

Prof. Da-Wei Fu, Dr. Ji-Xing Gao, Wen-Hui He, Xue-Qin Huang, Yu-Hua Liu, Prof. Yong Ai

, Angewandte Chemie, Volume132, Issue40 September 28, 2020 Pages 17630-17634

… [rac, R, and S-2-Me-H 2 dabco]Cl 2 were synthesized from the starting material of (rac, R, and S)-4-N-boc-2-methylpiperazine, respectively. The synthetic route is outlined in Scheme 2. …

147081-29-6 Process route

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-2-methylpiperazine
74879-18-8

(S)-2-methylpiperazine

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
147081-29-6

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 16h;
90%
With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 16h;
90%
With hydrogenchloride; In methanol; water; at 15 - 20 ℃; for 16h; Inert atmosphere; Industrial scale;
86%
In dichloromethane; at 20 ℃; for 4h;
84%
In dichloromethane; at 0 - 20 ℃; for 4h;
84%
With triethylamine; In dichloromethane; for 5h;
80%
With hydrogenchloride; In methanol; water; at 15 - 30 ℃; for 18h; Temperature; Solvent;
76.4%
In dichloromethane; at 0 - 20 ℃;
49%
With triethylamine; In methanol; for 17h;
 
With triethylamine; In hexane; dichloromethane; ethyl acetate;
 
With triethylamine; In methanol; for 17h;
 
With triethylamine; In dichloromethane; at 0 ℃; for 2h;
562 mg
With triethylamine; In hexane; dichloromethane;
 
(S)-2-methylpiperazine
74879-18-8

(S)-2-methylpiperazine

(S)-(-)1-(t-butoxycarbonyl)-2-t-butyl-3-methyl-4-imidazolidinone
136086-22-1

(S)-(-)1-(t-butoxycarbonyl)-2-t-butyl-3-methyl-4-imidazolidinone

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
147081-29-6

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Conditions
Conditions Yield
With triethylamine; In chloroform; at 20 ℃; for 15h;
 
With triethylamine; In chloroform;
 
With triethylamine; In chloroform;
 

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