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163765-44-4

  • Product Name(R)-4-Boc-2-methylpiperazine
  • Molecular FormulaC10H20N2O2
  • Molecular Weight200.281
  • Purity99%
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Product Details

Quick Details

  • CasNo： 163765-44-4
  • Molecular Formula： C10H20N2O2
  • Purity： 99%

High Quality (R)-4-Boc-2-methylpiperazine 163765-44-4 Crystalline Powder

  • Molecular Formula:C10H20N2O2
  • Molecular Weight:200.281
  • Melting Point:40-45 °C 
  • Boiling Point:268.7 °C at 760 mmHg 
  • PKA:8.52±0.40(Predicted) 
  • Flash Point:116.3 °C 
  • PSA：41.57000 
  • Density:0.997 g/cm3 
  • LogP:1.48190 

(R)-4-Boc-2-methylpiperazine(Cas 163765-44-4) Usage

Chemical Properties

White solid

Uses

(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid

IUPAC Name: tert-butyl (3R)-3-methylpiperazine-1-carboxylate  
Isomeric SMILES: C[C@@H]1CN(CCN1)C(=O)OC(C)(C)C  
InChIKey: FMLPQHJYUZTHQS-MRVPVSSYSA-N  
InChI: InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m1/s1  

163765-44-4 Relevant articles

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Qingbei Zeng†, Jiabing Wang†, Ziqiang Cheng†, Kan Chen†, Peter Johnström‡§, Katarina Varnäs§, David Yunzhi Li†, Zhen Fan Yang†, and Xiaolin Zhang*†

, J. Med. Chem. 2015, 58, 20, 8200–8215

Pyridine (18 g, 225 mmol) was added dropwise to a mixture of triphosgene (23 g, 75 mmol) in dry dichloromethane (250 mL) followed by (R)-4-boc-2-methylpiperazine (7) (15 g, 75 …

Preparation method of novel anti-cancer drug AZD3759

-

Paragraph 0073; 0076; 0083; 0086, (2020/09/30)

The invention provides a preparation met...

1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings

Rocaboy, Ronan,Baudoin, Olivier

supporting information, p. 1434 - 1437 (2019/02/19)

1,n-Metal shift is an elegant alternativ...

163765-44-4 Process route

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2R)-methylpiperazine
75336-86-6

(2R)-methylpiperazine

(R)-tert-butyl 3-methylpiperazine-1-carboxylate
163765-44-4

(R)-tert-butyl 3-methylpiperazine-1-carboxylate

Conditions
Conditions Yield
In dichloromethane; at 0 - 20 ℃; for 4h;
84%
In dichloromethane; at 0 - 20 ℃;
50%
In dichloromethane; at 0 - 20 ℃;
50%
In tetrahydrofuran; at 20 ℃; for 12h;
48%
With triethylamine; In hexane; dichloromethane; ethyl acetate;
 
In tetrahydrofuran; at 20 ℃; for 18h;
 
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.75h;
 
With triethylamine; In hexane; dichloromethane;
 
In chloroform; for 1h;
 
With pyridine; In dichloromethane; at 0 - 20 ℃;
 
In dichloromethane; at 0 ℃; for 1h;
25 g
In dichloromethane; at 0 ℃; for 1h;
26 g
In dichloromethane; at 0 ℃; for 1h;
25.4 g
(2R)-methylpiperazine
75336-86-6

(2R)-methylpiperazine

(R)-tert-butyl 3-methylpiperazine-1-carboxylate
163765-44-4

(R)-tert-butyl 3-methylpiperazine-1-carboxylate

Conditions
Conditions Yield
 
 96%

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