71989-38-3

  • Product NameFmoc-O-tert-butyl-L-tyrosine,Fmoc-Tyr(tBu)-OH
  • Molecular FormulaC28H29NO5
  • Molecular Weight459.542
  • Purity99%
  • Appearancewhite to light yellow crystal powder
Inquiry

Product Details

Quick Details

  • CasNo: 71989-38-3
  • Molecular Formula: C28H29NO5
  • Appearance: white to light yellow crystal powder
  • Purity: 99%

Fmoc-O-tert-butyl-L-tyrosine / Fmoc-Tyr(tBu)-OH 71989-38-3 Powder

  • Molecular Formula:C28H29NO5
  • Molecular Weight:459.542
  • Appearance/Colour:white to light yellow crystal powder 
  • Vapor Pressure:3.2E-18mmHg at 25°C 
  • Melting Point:153-156 °C 
  • Refractive Index:-30 ° (C=1, DMF) 
  • Boiling Point:658.2 °C at 760 mmHg 
  • PKA:2.97±0.10(Predicted) 
  • Flash Point:351.9 °C 
  • PSA:84.86000 
  • Density:1.218 g/cm3 
  • LogP:5.78920 

Fmoc-O-tert-butyl-L-tyrosine(Cas 71989-38-3) Usage

Chemical Properties

white to light yellow crystal powde

Uses

Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain. It is used in a variety of biological and biochemical research applications, including in vivo and in vitro studies.

General Description

N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine (Fmoc-Tyr(tbu)-OH) is a self-assembled structure formed by modified single amino acids.

InChI:InChI=1/C28H29NO5/c1-28(2,3)34-19-14-12-18(13-15-19)16-25(26(30)31)29-27(32)33-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,29,32)(H,30,31)

Fmoc-Tyr(tBu)-OH 71989-38-3 Relevant articles

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Einsiedler, Manuel,Jamieson, Cooper S.,Maskeri, Mark A.,Houk, Kendall N.,Gulder, Tobias A. M.

supporting information, p. 8297 - 8302 (2021/03/01)

Previous studies showed that the FeII/α-...

Method for preparing Fmoc-Tyr (tBu)-OH

-

Paragraph 0052; 0056; 0062; 0066-0067; 0071-0072; 0076-0077, (2020/12/30)

The invention relates to a method for pr...

Gram-positive marine bacteria as a potential resource for the discovery of quorum sensing inhibitors

Margaret E. Teasdale, Kellye A. Donovan, Stephanie R. Forschner-Dancause & David C. Rowley

Marine Biotechnology volume 13, pages722–732 (2011)

Fmoc-O-tert-butyl-l-tyrosine (1.44 mmol, 1.2 eq) in 50 mL acetonitrile was treated with HBTU (1.4 eq), diisopropylethylamine (1.5 eq), and l-proline methyl ester (1.2 mmol, 1 eq).  …

71989-38-3 Process route

N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine Methyl Ester
132409-94-0

N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine Methyl Ester

Fmoc-Tyr(tBu)-OH
71989-38-3,118488-18-9,204384-67-8

Fmoc-Tyr(tBu)-OH

Conditions
Conditions Yield
With lithium iodide; In ethyl acetate; Reagent/catalyst; Reflux;
84.3%
With sodium carbonate; In acetonitrile; for 15h;
74%
Fmoc-Tyr(t-Bu)-1,1-dimethylallyl ester
851713-94-5

Fmoc-Tyr(t-Bu)-1,1-dimethylallyl ester

Fmoc-Tyr(tBu)-OH
71989-38-3,118488-18-9,204384-67-8

Fmoc-Tyr(tBu)-OH

Conditions
Conditions Yield
With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 25 ℃;
91%

71989-38-3 Upstream products

  • 132409-94-0
    132409-94-0

    N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine Methyl Ester

  • 146346-74-9
    146346-74-9

    Fmoc-Tyr(but)-O-Pha

  • 851713-94-5
    851713-94-5

    Fmoc-Tyr(t-Bu)-1,1-dimethylallyl ester

  • 112883-29-1
    112883-29-1

    N-Fmoc-Tyr-OH

71989-38-3 Downstream products

  • 113548-12-2
    113548-12-2

    Fmoc-Tyr(tBu)-OTDO

  • 86060-93-7
    86060-93-7

    Fmoc-Tyr(tBu)-OPfp

  • 133956-73-7
    133956-73-7

    Fmoc-Tyr(t-Bu)-Gln-Gly-Lys(Z)-OH

  • 141971-81-5
    141971-81-5

    Ac-Tyr(t-Bu)-Gly-Gly-OMe

;