What is the Fmoc-O-tert-Butyl-L-serine?

Fmoc-O-tert-Butyl-L-serine is white to light yellow crystal powder, while it's Molecular Formula is C22H25NO5. white to light yellow crystal powder Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.

What is the CAS number for Fmoc-O-tert-Butyl-L-serine?

The CAS number of Fmoc-O-tert-Butyl-L-serine is 71989-33-8.

What is the Fmoc-O-tert-Butyl-L-serine?

Fmoc-O-tert-Butyl-L-serine is white to light yellow crystal powder, while it's Molecular Formula is C22H25NO5. white to light yellow crystal powder Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.

What is the CAS number for Fmoc-O-tert-Butyl-L-serine?

The CAS number of Fmoc-O-tert-Butyl-L-serine is 71989-33-8.

Fmoc-O-tert-Butyl-L-serine / Fmoc-Ser(tbu)-OH 71989-33-8 with Best Price

Product Details

Quick Details

CasNo： 71989-33-8
Molecular Formula： C₂₂H₂₅NO₅
Appearance： white to light yellow crystal powder
Purity： 99%

Fmoc-O-tert-Butyl-L-serine / Fmoc-Ser(tbu)-OH 71989-33-8 with Best Price

Molecular Formula:C22H25NO5
Molecular Weight:383.444
Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:3.16E-14mmHg at 25°C
Melting Point:127-131 °C
Refractive Index:24 ° (C=1, AcOEt)
Boiling Point:578.6 °C at 760 mmHg
PKA:3.44±0.10(Predicted)
Flash Point:303.7 °C
PSA：84.86000
Density:1.216 g/cm³
LogP:4.18430

Fmoc-O-tert-Butyl-L-serine(Cas 71989-33-8) Usage

Chemical Properties	white to light yellow crystal powde
Uses	Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. It also can be used as polymer-supported. Fmoc-O-tert-Butyl-L-serine is commercially available.
General Description	Fmoc-Thr(tbu)-OH self-assembles to sphere at lower concentration which changes to dumb-bell shapes at higher concentration under room temperature conditions.

InChI:InChI=1/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/p-1/t19-/m0/s1

71989-33-8 Relevant articles

Racemization studies of Fmoc-Ser (tBu)-OH during stepwise continuous-flow solid-phase peptide synthesis

A Di Fenza, M Tancredi, C Galoppini, P Rovero - Tetrahedron letters, 1998

We observed unexpectedly high levels of racemization of Fmoc-Ser(tBu)-OH during automated … We describe unexpectedly high levels of racemization of Fmoc-Ser(tBu)-OH during …

Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives

Petra Králová†∥, Veronika Fülöpová‡∥, Michal Maloň§, Tereza Volná†, Igor Popa†, and Miroslav Soural*‡

ACS Comb. Sci. 2017, 19, 3, 173–180

Herein we report the polymer-supported synthesis of 3,4-dihydro-2H-1,4-oxazine-3-carboxylic acid derivatives using immobilized Fmoc-Ser(tBu)-OH and Fmoc-Thr(tBu)-OH as the starting materials.

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

X Cheng, L Li, M Uttamchandani, SQ Yao

Chemical Communications, 2014

Briefly, Fmoc-O-tert-butyl-L-serine was coupled with propargylamine, giving 2, which was reacted with 2-chloroacetyl chloride upon Fmoc deprotection. The resulting intermediate 4 was …

71989-33-8 Process route

: 129460-16-8
(S)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Conditions

Conditions	Yield
With silica gel; In toluene; for 1.25h; Heating;	76% 8%

: Fmoc-Ser(tBu)-OMe

: 71989-33-8
Fmoc-Ser(tBu)-OH

Conditions

Conditions	Yield
With magnesium iodide; In tetrahydrofuran; at 120 ℃; for 1h; chemoselective reaction; Inert atmosphere; Microwave irradiation; Sealed tube;	98%
With aluminum (III) chloride; In ethyl acetate; Reflux;	86%

71989-33-8 Upstream products

18822-58-7
(S)-O-tert-butylserine
102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate
82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
132776-33-1
O-tert-Butyl-L-serine Methyl Ester p-Toluenesulfonate

71989-33-8 Downstream products

71989-34-9
Fmoc-Ser(t-Bu)-ONp
113534-37-5
Fmoc-Ser(tBu)-OTDO
176842-74-3
N-(9-fluorenylmethoxycarbonyl)-O-(tert-butyl)-L-seryl-L-proline benzyl ester
105751-13-1
O-tert-butyl-N^α-(fluoren-9-ylmethoxycarbonyl)-L-serine pentafluorophenyl ester

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71989-33-8

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Fmoc-O-tert-Butyl-L-serine / Fmoc-Ser(tbu)-OH 71989-33-8 with Best Price

Fmoc-O-tert-Butyl-L-serine(Cas 71989-33-8) Usage

71989-33-8 Relevant articles

Racemization studies of Fmoc-Ser (tBu)-OH during stepwise continuous-flow solid-phase peptide synthesis

A Di Fenza, M Tancredi, C Galoppini, P Rovero - Tetrahedron letters, 1998

Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives

Petra Králová†∥, Veronika Fülöpová‡∥, Michal Maloň§, Tereza Volná†, Igor Popa†, and Miroslav Soural*‡

ACS Comb. Sci. 2017, 19, 3, 173–180

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

X Cheng, L Li, M Uttamchandani, SQ Yao

Chemical Communications, 2014

71989-33-8 Process route

71989-33-8 Upstream products

71989-33-8 Downstream products

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