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Product Details
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Chemical Properties |
White powder |
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Uses |
Fmoc group molecules were reported to have a stable structure, were widely used reagents for a variety of chemical formations, and are important intermediates in the synthesis of pharmaceuticals due to their ability to protect amine groups. Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a: Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters . |
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General Description |
The Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-L-Glu(OtBu)) is a Fmoc derivative with an N-substituted tert‑butyl ester molecule. |
InChI:InChI=1/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1
The invention relates to the field of or...
For the derivatives conjugated with an albumin binder, Fmoc-Lys(Mtt)-OH, Fmoc-Glu(OtBu)-OH and 4-(p-iodophenyl)butyric acid were used before coupling DOTA chelator. …
In this study, the solvation effects, structural characterization, and biological properties of the Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-L-Glu(OtBu)) were described with …
Preparation of Glu(OtBu)-bonded silica (Glu(OtBu)-Sil) Firstly, Fmoc-Glu(OtBu)-OH (3.0 g) … Secondly, the carboxyl groups of Fmoc-Glu(OtBu)-OH were activated by adding 0.8 g of NHS …
![4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid allyl ester](/upload/2023/6/f3499b7c-756b-4392-acd9-e90501c695f3.png)
4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid allyl ester
Fmoc-Glu(OtBu)-OH
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With [2-(dicyclohexylphosphino)ethyl]trimethylammonium chloride; phenylsilane; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
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87% |
Fmoc-Glu(t-Bu)-1,1-dimethylallyl ester
Fmoc-Glu(OtBu)-OH
| Conditions | Yield |
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With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 25 ℃;
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87% |
L-glutamic acid 5-tert-butyl ester
9-fluorenylmethyl N-succinimidyl carbonate
(9-fluorenyl)methyl pentafluorophenyl carbonate
L-glutamic acid
Fmoc-Glu(OtBu)-OTDO
Nα-Fmoc-Glu-(O-tBu)-OPfp
tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate
Fmoc-L-Glu(OtBu)-OH
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