71989-18-9

  • Product NameFmoc-L-glutamic acid 5-tert-butyl ester,Fmoc-Glu(OtBu)-OH
  • Molecular FormulaC24H27NO6
  • Molecular Weight425.481
  • Purity99%
  • AppearanceWhite powder
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Product Details

Quick Details

  • CasNo: 71989-18-9
  • Molecular Formula: C24H27NO6
  • Appearance: White powder
  • Purity: 99%

Factory Supply Fmoc-L-glutamic acid 5-tert-butyl ester 71989-18-9 (Fmoc-Glu(OtBu)-OH)

  • Molecular Formula:C24H27NO6
  • Molecular Weight:425.481
  • Appearance/Colour:White powder 
  • Vapor Pressure:3.72E-17mmHg at 25°C 
  • Melting Point:83-90 °C 
  • Refractive Index:-4 ° (C=1, 80% AcOH) 
  • Boiling Point:638.1 °C at 760 mmHg 
  • PKA:3.70±0.10(Predicted) 
  • Flash Point:339.7 °C 
  • PSA:101.93000 
  • Density:1.232 g/cm3 
  • LogP:4.49110 

Fmoc-L-glutamic acid 5-tert-butyl ester(Cas 71989-18-9) Usage

Chemical Properties

White powder

Uses

Fmoc group molecules were reported to have a stable structure, were widely used reagents for a variety of chemical formations, and are important intermediates in the synthesis of pharmaceuticals due to their ability to protect amine groups. Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a: Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

General Description

The Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-L-Glu(OtBu)) is a Fmoc derivative with an N-substituted tert‑butyl ester molecule.

InChI:InChI=1/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1

Fmoc-Glu(OtBu)-OH 71989-18-9 Relevant articles

High-efficiency industrial production method of Fmoc-Glu (Otbu)-OH

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Paragraph 0026; 0031-0035; 0040-0043, (2020/02/19)

The invention relates to the field of or...

Enhancing Tumor Uptake for 177Lu-Labeled MC1R Targeting Radioligands by Combining N-Methylations with an Albumin Binder

C Zhang, Z Zhang, J Zeisler, N Colpo, KS Lin, F Benard

Journal of Nuclear Medicine May 2020, 61 (supplement 1) 378;

For the derivatives conjugated with an albumin binder, Fmoc-Lys(Mtt)-OH, Fmoc-Glu(OtBu)-OH and 4-(p-iodophenyl)butyric acid were used before coupling DOTA chelator.  …

Spectral characterization, solvation effects on topological aspects, and biological attributes of Fmoc-L-glutamic acid 5‑tert‑butyl ester: An effective reagent in anticancer evaluations

M. Thirunavukkarasu a b, G. Balaji b, P. Prabakaran c, Shaik Jaheer Basha d, Ahmad Irfan e, S Saleem Javed f, S. Muthu g

Journal of Molecular Structure Volume 1269, 5 December 2022, 133793

In this study, the solvation effects, structural characterization, and biological properties of the Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-L-Glu(OtBu)) were described with …

Preparation, chromatographic evaluation and comparison between linear peptide-and cyclopeptide-bonded stationary phases

J Li, Y Li, T Chen, L Xu, X Liu, X Zhang, H Zhang

Talanta, 2013

Preparation of Glu(OtBu)-bonded silica (Glu(OtBu)-Sil) Firstly, Fmoc-Glu(OtBu)-OH (3.0 g) … Secondly, the carboxyl groups of Fmoc-Glu(OtBu)-OH were activated by adding 0.8 g of NHS …

71989-18-9 Process route

4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid allyl ester

4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid allyl ester

Fmoc-Glu(OtBu)-OH
71989-18-9

Fmoc-Glu(OtBu)-OH

Conditions
Conditions Yield
With [2-(dicyclohexylphosphino)ethyl]trimethylammonium chloride; phenylsilane; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
87%
Fmoc-Glu(t-Bu)-1,1-dimethylallyl ester
851713-96-7

Fmoc-Glu(t-Bu)-1,1-dimethylallyl ester

Fmoc-Glu(OtBu)-OH
71989-18-9

Fmoc-Glu(OtBu)-OH

Conditions
Conditions Yield
With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 25 ℃;
87%

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