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166108-71-0

  • Product Name[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, Fmoc-AeeAc-OH
  • Molecular FormulaC21H23NO6
  • Molecular Weight385.417
  • Purity99%
  • Appearancewhite crystal
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Product Details

Quick Details

  • CasNo： 166108-71-0
  • Molecular Formula： C21H23NO6
  • Appearance： white crystal
  • Purity： 99%

Fmoc-AeeAc-OH / [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 15295-77-9 Factory

  • Molecular Formula:C21H23NO6
  • Molecular Weight:385.417
  • Appearance/Colour:white crystal 
  • Vapor Pressure:8.27E-17mmHg at 25°C 
  • Melting Point:90-92℃ 
  • Refractive Index:1.579 
  • Boiling Point:631.4 °C at 760 mmHg 
  • PKA:3.40±0.10(Predicted) 
  • Flash Point:335.6 °C 
  • PSA：94.09000 
  • Density:1.265 g/cm3 
  • LogP:3.03380 

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid(Cas 166108-71-0) Usage

Uses

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer. [2-[2-(Fmoc-amino)-ethoxy]- ethoxy]acetic acid (Fmoc-AEEAc-OH, AnaSpec) residues can be used as PEG spacers. [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a coupling agent used in the synthesis of polypeptides or peptides. It is useful to attach chromophores.

Description

Fmoc-AEEAc-OH. Also known as (PEG)2 or Fmoc-8-amino-3,6-dioxaoctanoic acid, is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media.

Chemical Properties

White solid

InChI:InChI=1/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)

Fmoc-AeeAc-OH 166108-71-0 Relevant articles

Forced peptide synthesis in nanoscale confinement under elastomeric stamps

Terena P. Sullivan, Maaike L. van Poll, Patricia Y. W. Dankers Dr., Wilhelm T. S. Huck Dr.

Angewandte Chemie International Edition,Volume43, Issue32 August 13, 2004 Pages 4190-4193

The first step involved printing a {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid (Fmoc-AEEA-OH) linker onto an aminopropyltrimethoxysilane (APTS) SAM on silicon. Subsequent …

Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy

Guy Mann‡ a, Gandhesiri Satish‡ a, Prasad Sulkshane‡ b, Shaswati Mandal a, Michael H. Glickman *b and Ashraf Brik

Chem. Commun., 2021, 57, 9438-9441

(TAMRA), (2) a Cys for … {2[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid (PEG) as a spacer between Ub and the unnatural elements. Employing Fmoc-SPPS on a 2-chlorotrityl chloride (2-…

Development of homomultimers and heteromultimers of lung cancer‐specific peptoids

Jared C. Hooks, Jaya P. Matharage, D. Gomika Udugamasooriya

,Peptide Science, 2011

In this regard, Fmoc-β-Ala-OH was chosen as the shorter spacer and Fmoc-AEEAc-OH as the longer spacer. Six-carbon long Fmoc-ε-Ahx-OH will be another choice, even though it …

166108-71-0 Process route

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol
6338-55-2

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid
166108-71-0,675606-79-8

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / water / Inert atmosphere
2: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / dichloromethane / Inert atmosphere
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; In dichloromethane; water;
 
8-(9-fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid tert-butyl ester

8-(9-fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid tert-butyl ester

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid
166108-71-0,675606-79-8

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

Conditions
Conditions Yield
With trifluoroacetic acid; In dichloromethane; for 2h;
100%

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