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15295-77-9

  • Product NameL-HOMOSERINE LACTONE HYDROBROMIDE
  • Molecular FormulaC4H7 N O2 . Br H
  • Molecular Weight182.017
  • Purity99%
  • AppearanceWHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER
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Product Details

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  • CasNo： 15295-77-9
  • Molecular Formula： C4H7 N O2 . Br H
  • Appearance： WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER
  • Purity： 99%

High Purity L-HOMOSERINE LACTONE HYDROBROMIDE 15295-77-9 solid

  • Molecular Formula:BrH*C4H7NO2
  • Molecular Weight:182.017
  • Appearance/Colour:WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER 
  • Vapor Pressure:0.00233mmHg at 25°C 
  • Melting Point:225 °C (dec.)(lit.)
     
  • Boiling Point:281.4°Cat760mmHg 
  • Flash Point:124°C 
  • PSA：52.32000 
  • Density:g/cm3 
  • LogP:0.91900 

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE(Cas 15295-77-9) Usage

Chemical Properties

WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER
Description L-Homoserine Lactone Hydrobromide is a reactant in the synthesis of tritium labeled and photoactivatable N-acyl-L-homoserine lactones.

Uses

L-Homoserine lactone hydrobromide is used as a building block.

InChI:InChI=1/C4H7NO2.BrH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

15295-77-9 Relevant articles

Biological Evaluation and Docking Studies of New Carbamate, Thiocarbamate, and Hydrazide Analogues of Acyl Homoserine Lactones as Vibrio fischeri-Quorum Sensing Modulators

Qiang Zhang,Yves Queneau * andLaurent Soulère *

, Biomolecules 2020, 10(3), 455;

l- or d-homoserine lactone hydrobromide was synthesized … and was then reacted with l-homoserine lactone (route A). In … reaction with l-homoserine lactone or (d-homoserine lactone for …

Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities

MS Majik, UB Gawas, VK Mandrekar

Bioorganic & Medicinal Chemistry, 2020

A homoserine lactone hydrobromide 19, was prepared by refluxing l-methionine 18 with … N-(3-oxo-octanoyl)-l-homoserine lactone (OOHL) binding site and binding ability of the …

Preparation of D-, DL-, and L-homoserine lactone from methionine

S Natelson, EA Natelson

Microchemical journal, 1989

15 g of the homoserine lactone hydrobromide (ca. 80%). … 60 mmol) of the homoserine lactone hydrobromide was sus… The hydrobromide gradually dissolved and KBr precipitated. …

15295-77-9 Process route

L-methionine
63-68-3,26062-47-5,58576-49-1

L-methionine

bromoacetic acid
79-08-3

bromoacetic acid

methylsulfanyl-acetic acid
2444-37-3

methylsulfanyl-acetic acid

thiodiacetic acid
123-93-3

thiodiacetic acid

(S)-(-)-α-amino-γ-butyrolactone hydrobromide
6305-38-0,15295-77-9,67580-93-2,110045-70-0

(S)-(-)-α-amino-γ-butyrolactone hydrobromide

Conditions
Conditions Yield
In water; at 80 ℃; for 8h; Overall yield = 303.4 g;
 
L-methionine
63-68-3,26062-47-5,58576-49-1

L-methionine

(S)-(-)-α-amino-γ-butyrolactone hydrobromide
6305-38-0,15295-77-9,67580-93-2,110045-70-0

(S)-(-)-α-amino-γ-butyrolactone hydrobromide

Conditions
Conditions Yield
With bromoacetic acid; In water; acetic acid; isopropyl alcohol; Reflux; Inert atmosphere;
86%
With bromoacetic acid; In water; acetic acid; isopropyl alcohol; for 9h; Heating;
81%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; Reflux;
With hydrogenchloride; at 50 ℃; for 0.166667h;
75%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; for 12h; Inert atmosphere; Reflux;
With hydrogen bromide; In isopropyl alcohol; Cooling;
75%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; at 20 - 95 ℃; Industry scale;
With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 20 - 60 ℃; Industry scale;
70%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; Reflux;
With hydrogenchloride; at 55 ℃; for 0.5h;
55%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; for 2h; Reflux;
With hydrogenchloride; In 1,4-dioxane; water; at 50 ℃;
52%
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; for 8h; Reflux;
With hydrogenchloride; In 1,4-dioxane; at 20 - 50 ℃; for 5.16667h;
52%
With acetic acid; bromoacetic acid; In water; isopropyl alcohol; for 2h; Reflux;
45%
Yield given. Multistep reaction;
 
L-methionine; With bromoacetic acid; In water; acetic acid; isopropyl alcohol; for 2h; Heating / reflux;
With hydrogenchloride; In 1,4-dioxane; water; at 50 ℃;
 
With bromoacetic acid; In [D3]acetonitrile; water; isopropyl alcohol; Reflux;
 
L-methionine; With acetic acid; bromoacetic acid; In water; isopropyl alcohol; Reflux;
With hydrogen bromide; In isopropyl alcohol;
 

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