What is the D-Valine?

D-Valine is white to off-white crystalline powder, while it's Molecular Formula is C5H11NO2. white to off-white crystalline powder D-Valine is an isomer of the essential amino acid L-Valine. D-Valine has been used as a selective agent in epithelial cells in culture since it inhibits cells that lack the enzyme D-amino acid oxidase. D-Valine has also been shown to inhibit proliferation of contaminating fibroblasts in smooth muscle cells from human myometrium. D-Valine solution showed tumor growth inhibition and improvements of the nutritional status in AH109A hepatoma-bearing rats.

What is the CAS number for D-Valine?

The CAS number of D-Valine is 640-68-6.

What is D-Valine (640-68-6) used for?

D-valine is the D-form of valine, being the non-proteinogenic isomer of valine. It can be supplemented into the cell culture for selectively inhibition of cell proliferation through inhibiting cells that are deficient in the enzyme D-amino acid oxidase. It has also been used to inhibit fibroblast growth while allowing the selective growth of epithelial cells.InChI:InChI=1/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

What is the D-Valine?

D-Valine is white to off-white crystalline powder, while it's Molecular Formula is C5H11NO2. white to off-white crystalline powder D-Valine is an isomer of the essential amino acid L-Valine. D-Valine has been used as a selective agent in epithelial cells in culture since it inhibits cells that lack the enzyme D-amino acid oxidase. D-Valine has also been shown to inhibit proliferation of contaminating fibroblasts in smooth muscle cells from human myometrium. D-Valine solution showed tumor growth inhibition and improvements of the nutritional status in AH109A hepatoma-bearing rats.

What is the CAS number for D-Valine?

The CAS number of D-Valine is 640-68-6.

What is D-Valine (640-68-6) used for?

D-valine is the D-form of valine, being the non-proteinogenic isomer of valine. It can be supplemented into the cell culture for selectively inhibition of cell proliferation through inhibiting cells that are deficient in the enzyme D-amino acid oxidase. It has also been used to inhibit fibroblast growth while allowing the selective growth of epithelial cells.InChI:InChI=1/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

API D-Valine 640-68-6 In Medicine

Product Details

Quick Details

CasNo： 640-68-6
Molecular Formula： C₅H₁₁NO₂
Appearance： white to off-white crystalline powder
Purity： 99%

API D-Valine 640-68-6 In Medicine

Molecular Formula:C5H11NO2
Molecular Weight:117.148
Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:0.0633mmHg at 25°C
Melting Point:>295 °C (subl.)(lit.)
Refractive Index:-27 ° (C=8, 6mol/L HCl)
Boiling Point:213.6 °C at 760 mmHg
PKA:2.37±0.10(Predicted)
Flash Point:83 °C
PSA：63.32000
Density:1.063 g/cm³
LogP:0.75460

D-Valine(Cas 640-68-6) Usage

Description	D-valine is the D-form of valine, being the non-proteinogenic isomer of valine. It can be supplemented into the cell culture for selectively inhibition of cell proliferation through inhibiting cells that are deficient in the enzyme D-amino acid oxidase.
Uses	D-valine can be used for the synthesis of newly efficient pesticide: pyrethroids permethrin and chlorofluorocarbons amyl because of its own biochemical characteristics. D-Valine is an important organic chiral source which is mainly used in fields such as chiral pharmaceuticals, chiral additive, and chiral auxiliary and other areas. D-valine is the intermediates for fluvalinate. It is used as a pharmaceutical raw materials and pharmaceutical intermediates, and can also be used for synthetic sweeteners Alatan. It can also be used for biochemical research. D-valine hydrogel can reduce inflammatory factor level, reduce alveolar bone resorption, and improve periodontitis, which may be related to periodontal pathogens.
Chemical Properties	White crystal, m.p.> 295 °C (sublimation), [α] 25 = 27.35°; it is soluble in water and very slightly soluble in ethanol.
Production methods	1. DL-Acetyl-methionine is used as the raw material. It undergoes acylase splitting, and further hydrochloric acid acidification to have D-valine crystals precipitated; refined product is finally obtained through recrystallization. 2. The preparation method is to use 2-isopropyl-acetyl ethyl to react with benzene diazonium to get corresponding hydrazine compound, and then further reduce it to valine in zinc-ethanol solution and finally go through chemical or biological split.
Definition	ChEBI: The D-enantiomer of valine.
General Description	L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine. The demand for D-Valine increases because of its wide range of use.

Isomeric SMILES: CC(C)[C@H](C(=O)O)N
InChIKey: KZSNJWFQEVHDMF-SCSAIBSYSA-N
InChI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

640-68-6 Relevant articles

A novel process using immobilized engineered strain HC01 cells with co-expressed D-hydantoinase and D-N-carbamoylase as biocatalyst for the production of D-Valine

Lixi Niu, Lulu Xie, Jiao Ji & Lihua Lv

Bioprocess and Biosystems Engineering volume 46, pages227–236 (2023)

This method provides D-Valine with optical purity of 97% and an overall yield of 72%. Furthermore, the immobilized cells can be reused for more than 7 cycles and maintain their capacity of over 70%. Hence the immobilized cells of engineered strain HC01 could potentially be used to prepare D-Valine.

Single-Cell-Based Screening and Engineering of d -Amino Acid Amidohydrolases Using Artificial Amidophenol Substrates and Microbial Biosensors

An, Jung-Ung,Kim, Haseong,Kwon, Kil Koang,Lee, Dae-Hee,Lee, Hyewon,Lee, Jin-Young,Lee, Seung-Goo,Park, Sung Hyun,Rha, Eugene,Yeom, Soo-Jin

, p. 1203 - 1211 (2022/01/27)

Enantiomerically pure d-amino acids are ...

Structural, optical, FT-IR and SHG studies of L-Isoleucine D-Valine: A spectroscopic and DFT approach

G. Govindharajan a, S. Jeyaseelan b, S. Pari a, A. Shiny Febena c

Materials Today: Proceedings,Volume 50, Part 7, 2022, Pages 2627-2631

In this work, efficient NLO single crystal of L-Isoleucine D-Valine (LIDV) was grown successfully by employing slow evaporation method-the simplest method. …

640-68-6 Process route

: 1187486-25-4
itralamide B

: 3913-67-5
N-methylalanine

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 2812-28-4
(2S,3R)-3-hydroxy-2-(methylamino)butanoic acid

: N-methylalanylvaline

: N-methylphenylalanylvaline

: 56564-52-4
N-methyl-D-phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride; water; at 110 ℃; for 18.5h;

: 1400276-81-4
(4aS,10aR,13S,19aR,21aS,26bR,27aS,30R)-24-chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,19a,22,26b,27,27a,29,30-icosahydro-25,26b-dihydroxy-12,13-dimethyl-30-(propan-2-yl)-7H,21aH-tripyridazino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’] [1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrrolo[2,3-b]indole-5,11,14,20,28,31(1H,16H)-hexone