351-50-8

  • Product NameD-Histidine
  • Molecular FormulaC6H9N3O2
  • Molecular Weight155.156
  • Purity99%
  • Appearancewhite crystalline powder
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Product Details

Quick Details

  • CasNo: 351-50-8
  • Molecular Formula: C6H9N3O2
  • Appearance: white crystalline powder
  • Purity: 99%

Wholesale High Quality D-Histidine 351-50-8

  • Molecular Formula:C6H9N3O2
  • Molecular Weight:155.156
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:3.25E-09mmHg at 25°C 
  • Melting Point:280-290 °C (dec.) 
  • Refractive Index:-13 ° (C=11, 6mol/L HCl) 
  • Boiling Point:458.9 °C at 760 mmHg 
  • PKA:1.91±0.10(Predicted) 
  • Flash Point:231.3 °C 
  • PSA:92.00000 
  • Density:1.423 g/cm3 
  • LogP:0.06440 

D-Histidine(Cas 351-50-8) Usage

Chemical Properties

white crystalline powder

Uses

D-Histidine is the unnatural, biologically inactive isomer of L-Histidine (H456010). D-histidine is known to inhibit cell division, and is also used by certain types of bacteria (such as Escherichia coli) as a source of L-Histidine.

Definition

ChEBI: An optically active form of histidine having D-configuration. D-histidine has a typical absorption peak at about 2.8 THz.

Biochem/physiol Actions

D-Histidine may be used in the design of peptide drugs, cationic peptides, such as analogues of carnosine. D-Histidine may also be used as a heavy metal sequestration agent. D-Histidine effectively inhibits Streptococcus mutan biofilm formation in a dose-dependent manner and D-Histidine interferes with the viability of Streptococcus mutans.

InChI:InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m1/s1

351-50-8 Relevant articles

Synergistic effects of D-arginine, D-methionine and D-histidine against Porphyromonas gingivalis biofilms

Zhenyang Zhang,Baosheng Li,Qing Cai,Shuwei Qiao,Dan Wang,Heling Wang,Huiyan Zhang,Yalan Yang &Weiyan Meng

Biofouling The Journal of Bioadhesion and Biofilm Research Volume 37, 2021 - Issue 2

In this study, D-arginine (R), D-methionine (M), D-histidine (H), and a mixture of these D-amino acids (D-AAs) were investigated as an effective therapeutic strategy against P. gingivalis biofilms.

Chromatographic Resolution of α-Amino Acids by (R)-(3,3'-Halogen Substituted-1,1'-binaphthyl)-20-crown-6 Stationary Phase in HPLC

Wu, Peng,Wu, Yuping,Zhang, Junhui,Lu, Zhenyu,Zhang, Mei,Chen, Xuexian,Yuan, Liming

supporting information, p. 1037 - 1042 (2017/07/25)

Three new chiral stationary phases (CSPs...

Complex structures, formation thermodynamics and substitution reaction kinetics in the copper (II)–glycylglycyl-l-tyrosine–l/d-histidine systems

Nikita Yu. Serov a, Valery G. Shtyrlin a, Mikhail S. Bukharov a, Anton V. Ermolaev a, Edward M. Gilyazetdinov a, Kira V. Urazaeva a, Alexander A. Rodionov b

Polyhedron Volume 228, 1 December 2022, 116176

Complex formation in the copper(II) – glycylglycyl-l-tyrosine and copper(II) – glycylglycyl-l-tyrosine – l/d-histidine systems was investigated by pH-potentiometric titration and spectrophotometry methods in the pH range 2–11.

351-50-8 Process route

D,L-histidine
71-00-1

D,L-histidine

L-histidine
71-00-1

L-histidine

D-histidin
351-50-8

D-histidin

Conditions
Conditions Yield
 
 
With borane-ammonia complex; oxygen; ammonium formate; L-amino acid oxidase; In water; for 5h; pH=6.7;
 
With 1-hexyl-3-methylimidazolium L-prolinate; copper(II) acetate monohydrate; In methanol; water; at 25 ℃; pH=5.8; Resolution of racemate; solid phase reaction;
 
With sulfuric acid; In methanol; water; at 25 ℃; Resolution of racemate;
 
With conjugated polyfluorene appended with protected L-glutamic acid; In water; for 48h; enantioselective reaction; Resolution of racemate;
49.55 % ee
His
4998-57-6,26062-48-6,90081-11-1

His

L-histidine
71-00-1

L-histidine

D-histidin
351-50-8

D-histidin

Conditions
Conditions Yield
durch fraktionierte Krystallisation des d-weinsaeuren Salzes; das Salz des d-Histidins krystallisiert zuerst aus;
 

351-50-8 Upstream products

  • 4998-57-6
    4998-57-6

    His

  • 71-00-1
    71-00-1

    L-histidine

  • 71-00-1
    71-00-1

    D,L-histidine

  • 75983-68-5
    75983-68-5

    Nα-acetyl-D-histidine

351-50-8 Downstream products

  • 2504-83-8
    2504-83-8

    β-imidazolyl pyruvic acid

  • 6893-26-1
    6893-26-1

    D-Glutamic acid

  • 71-00-1
    71-00-1

    L-histidine

  • 4467-54-3
    4467-54-3

    (R)-histidine methyl ester dihydrochloride

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