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328-38-1

  • Product NameD-Leucine
  • Molecular FormulaC6H13NO2
  • Molecular Weight131.175
  • Purity99%
  • Appearancewhite crystals
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Product Details

Quick Details

  • CasNo： 328-38-1
  • Molecular Formula： C6H13NO2
  • Appearance： white crystals
  • Purity： 99%

Food Additive D-Leucine 328-38-1 Powder

  • Molecular Formula:C6H13NO2
  • Molecular Weight:131.175
  • Appearance/Colour:white crystals 
  • Vapor Pressure:0.0309mmHg at 25°C 
  • Melting Point:300 ºC 
  • Refractive Index:-15 ° (C=4, 6mol/L HCl) 
  • Boiling Point:225.8 ºC at 760 mmHg 
  • PKA:2.55±0.21(Predicted) 
  • Flash Point:90.3 ºC 
  • PSA：63.32000 
  • Density:1.035 g/cm3 
  • LogP:1.14470 

D-2-Amino-4-methylpentanoic acid(Cas 328-38-1) Usage

Chemical Properties

White powder. Commercial D-leucine powder is composed of large flattened crystals of about 30 μm with ~3 μm thickness, while micronized budesonide appeared as small irregular crystals.

Uses

D‐Leucine (d‐Leu) is a d‐type amino acid found in foods and mammalian tissues. D-Leucine is used in the formation of sterols. It is also used as a selectable marker.

Definition

ChEBI: The D-enantiomer of leucine.

Isomeric SMILES: CC(C)C[C@H](C(=O)O)N  
InChIKey: ROHFNLRQFUQHCH-RXMQYKEDSA-N  
InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1  

328-38-1 Relevant articles

Encapsulation of l-valine, d-leucine and d-methionine by cucurbit[8]uril

Zeng-Hui Zhang,a   Rui-Lian Lin,b   Xiang-Yun Yu,a   Li-Xia Chen,a   Zhu Tao,a   Xin Xiao,  *a   Gang Wei,*c   Carl Redshawd  and  Jing-Xin Liu  *b

CrystEngComm, Issue 5, 2022

The binding interactions of cucurbit[8]uril (Q[8]) with L-valine, D-leucine, and D-methionine, both in aqueous solution and solid state, have been studied by 1H NMR spectroscopy and X-ray crystallography.

D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation

Author links open overlay panelAurélie Schoubben a, Riccardo Vivani a, Marco Paolantoni b, Diego Romano Perinelli c, Antimo Gioiello a, Antonio Macchiarulo a, Maurizio Ricci a

European Journal of Pharmaceutical Sciences Volume 130, 15 March 2019, Pages 54-64

The direct physical mixing of the atomized D-leucine with the micronized active pharmaceutical ingredient is a valid and economic alternative for the production of carrier-free dry powders for inhalation.

Adiponectin-Secretion-Promoting Cyclic Peptide-Polyketide Hybrids from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS0417

An, Seungchan,Bang, Sunghee,Deyrup, Stephen T.,Gong, Junpyo,Kim, Jaekyeong,Ko, Hyejin,Lee, Changyeol,Noh, Minsoo,Shim, Sang Hee

, (2022/03/02)

Three new cyclic peptide-polyketide hybr...

328-38-1 Process route

pholipeptin

pholipeptin

D-Serine
312-84-5,83245-15-2

D-Serine

L-threonine
72-19-5,134357-96-3,7013-32-3,82822-12-6

L-threonine

(R)-leucine
328-38-1,21675-61-6,25248-98-0,70-45-1

(R)-leucine

L-isoleucine
73-32-5,959215-79-3,18875-42-8

L-isoleucine

(2R)-aspartic acid
1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3

(2R)-aspartic acid

L-Aspartic acid
56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3

L-Aspartic acid

Conditions
Conditions Yield
With hydrogenchloride; at 120 ℃; for 20h; Product distribution;
 
des-thiomethyllooekeyolide A

des-thiomethyllooekeyolide A

(2S)-2-hydroxybutanoic acid
3347-90-8

(2S)-2-hydroxybutanoic acid

(R)-leucine
328-38-1,21675-61-6,25248-98-0,70-45-1

(R)-leucine

Conditions
Conditions Yield
With hydrogenchloride; In water; at 115 ℃; for 18h; Sealed tube;
 

328-38-1 Upstream products

  • 328-39-2
    328-39-2

    LEUCINE

  • 2899-43-6
    2899-43-6

    DL-leucine ethyl ester

  • 5338-45-4
    5338-45-4

    N-formyl-valine

  • 5338-45-4
    5338-45-4

    N-formyl-D-leucine

328-38-1 Downstream products

  • 29588-87-2
    29588-87-2

    (R)-2-(1,3-dioxoisoindolin-2-yl)-4-methylpentanoic acid

  • 66789-78-4
    66789-78-4

    N-[(2,4,5-trichloro-phenoxy)-acetyl]-D-leucine

  • 20312-37-2
    20312-37-2

    (R)-2-hydroxy-4-methylpentanoic acid

  • 80913-68-4
    80913-68-4

    N-[(2,4-Dichlor-phenoxy)-acetyl]-D-leucin

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