• Product NameD-Pyroglutamic acid
  • Molecular FormulaC5H7NO3
  • Molecular Weight129.115
  • Purity99%
  • Appearancewhite to light yellow crystal powder

Product Details

Quick Details

  • CasNo: 4042-36-8
  • Molecular Formula: C5H7NO3
  • Appearance: white to light yellow crystal powder
  • Purity: 99%

High Purity D-Pyroglutamic acid 4042-36-8 Good Supplier

  • Molecular Formula:C5H7NO3
  • Molecular Weight:129.115
  • Appearance/Colour:white to light yellow crystal powder 
  • Vapor Pressure:0.002mmHg at 25°C 
  • Melting Point:155-162 °C 
  • Refractive Index:10 ° (C=5, H2O) 
  • Boiling Point:453.1 °C at 760 mmHg 
  • PKA:3.48±0.20(Predicted) 
  • Flash Point:227.8 °C 
  • PSA:66.40000 
  • Density:1.38 g/cm3 
  • LogP:-0.32160 

D-Pyroglutamic acid(Cas 4042-36-8) Usage

Chemical Properties

white to light yellow crystal powde


D-pyroglutamic acid is an elicitor of reactive oxygen species (ROS). Serves as a building block in the synthesis of diphthamide


ChEBI: The D-enantiomer of 5-oxoproline. D-Pyroglutamic acid is a natural product found in Ascochyta medicaginicola, Spinacia oleracea, and other organisms with data available.

Purification Methods

Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. 

Isomeric SMILES: C1CC(=O)N[C@H]1C(=O)O  
InChI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m1/s1  

4042-36-8 Relevant articles

Synthesis of Optically Active Graft Copolymers Carrying Polylactide Arms as Fluorescent Sensor for Recognition of Pyroglutamic Acid Enantiomer

Q Li, Y Peng, S Han, T Lan, J Zhang, J Cao

ChemistrySelect, Volume5, Issue22 June 16, 2020 Pages 6549-6555

Because Cu 2+ is a tetracoordinate plane configuration, L-pyroglutamic acid is more likely to form stable coordination bond with Cu 2+ than D-pyroglutamic acid under the influence of …

Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability

Jantos, Katja,Kling, Andreas,Mack, Helmut,Hornberger, Wilfried,Moeller, Achim,Nimmrich, Volker,Lao, Yanbin,Nijsen, Marjoleen

supporting information, p. 1968 - 1973 (2019/05/29)

Aberrant activation of calpain has been ...

A molecularly imprinted gel photonic crystal sensor for recognition of chiral amino acids

X Qiu, Y Li, D Liu, K Zhou, Y Wang, H Guo

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume 283, 15 December 2022, 121719

Besides, MIPHs was found to have good selectivity toward l-pyroglutamic acid in the presence of interference group with similar structures such as d-pyroglutamic acid, l-tryptophan, l-…

Synthesis of tertiary and quaternary amine derivatives from wood resin as chiral NMR solvating agents

Laaksonen, Tiina,Heikkinen, Sami,W?h?l?, Kristiina

supporting information, p. 20873 - 20886 (2015/12/23)

Chiral tertiary and quaternary amine sol...

4042-36-8 Process route

D-Glutamic acid

D-Glutamic acid

D-pyrrolidone-5-carboxylic acid

D-pyrrolidone-5-carboxylic acid

Conditions Yield
With water; for 63h; Heating;
In water; for 72h; Heating;
With D-glutamate cyclase from mouse; In methanol; at 37 ℃; for 1h; pH=8; Kinetics; Enzymatic reaction;
With sodium hydroxide; In ethanol; water; at 20 ℃; for 48h;
With DL-dithiothreitol; D-glutamate cyclase; manganese(ll) chloride; In aq. buffer; at 37 ℃; for 1h; pH=8; Kinetics; Enzymatic reaction;


D-pyrrolidone-5-carboxylic acid

D-pyrrolidone-5-carboxylic acid

Conditions Yield
With oxygen; sodium hydrogencarbonate; platinum; In water; for 4h; Ambient temperature;

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