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Product Details
Chemical Properties |
White cryst. powder |
Uses |
D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. D-glutamic acid is an optically active form of glutamic acid having D-configuration. It helps in the growth of Lactobacillus arabinosus. It can inhibit the IgE binding to peanut allergens. Glutamic Acid is also a key molecule in cellular metabolism. |
Definition |
ChEBI: An optically active form of glutamic acid having D-configuration. |
General Description |
Glutamic acid is the most common excitatory neurotransmitter in the central nervous system. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan. |
Biological Activity |
Excitatory amino acid acting at NMDA receptors; less active than the L-isomer. |
Biochem/physiol Actions |
Unnatural isomer of glutamic acid. |
Isomeric SMILES: C(CC(=O)O)[C@H](C(=O)O)N
InChIKey: WHUUTDBJXJRKMK-GSVOUGTGSA-N
InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
Using cyclic voltammetry method, the anodic peak currents were found to have a linear relationship with the concentration of glutamic acids within the range between 0.5 and 15.0 mM, with a detection limit of 0.11 mM for L-glutamic acid and 0.26 mM for D-glutamic acid. The device-to-device reproducibility is great, confirming the robustness of this modification method.
The results suggested that Xanthine, 4-Pyridoxate, and d-glutamic acid may serve as potential biomarkers for pulmonary TB. The present study provides experimental basis for …
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D-Glutamic acid
4-nitro-aniline
Conditions | Yield |
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With marine bivalve lysozyme; MOPS buffer; Tapes japonica; at 37 ℃; pH=7.0; Enzyme kinetics;
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α-ketoglutaric acid
D-norvaline
D-Glutamic acid
2-oxopentanoic acid
Conditions | Yield |
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With pyridoxal 5'-phosphate; recombinant Lactobacillus salivarius UCC118 D-amino acid aminotransferase; In aq. phosphate buffer; at 30 ℃; for 0.0166667h; pH=7.5; Enzymatic reaction;
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