6893-26-1

  • Product NameD-Glutamic acid
  • Molecular FormulaC5H9NO4
  • Molecular Weight147.131
  • Purity99%
  • Appearancewhite crystalline powder
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Product Details

Quick Details

  • CasNo: 6893-26-1
  • Molecular Formula: C5H9NO4
  • Appearance: white crystalline powder
  • Purity: 99%

Food Grade D-Glutamic acid 6893-26-1 In Medicine

  • Molecular Formula:C5H9NO4
  • Molecular Weight:147.131
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:2.55E-05mmHg at 25°C 
  • Melting Point:200-202 °C 
  • Refractive Index:1.4210 (estimate) 
  • Boiling Point:333.8 °C at 760 mmHg 
  • PKA:pK1:2.162(+1);pK2:4.272(0);pK3:9.358(-1) (25°C) 
  • Flash Point:155.7 °C 
  • PSA:100.62000 
  • Density:1.409 g/cm3 
  • LogP:-0.03660 

D(-)-Glutamic acid(Cas 6893-26-1) Usage

Chemical Properties

White cryst. powder

Uses

D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. D-glutamic acid is an optically active form of glutamic acid having D-configuration. It helps in the growth of Lactobacillus arabinosus. It can inhibit the IgE binding to peanut allergens. Glutamic Acid is also a key molecule in cellular metabolism.

Definition

ChEBI: An optically active form of glutamic acid having D-configuration.

General Description

Glutamic acid is the most common excitatory neurotransmitter in the central nervous system. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Biological Activity

Excitatory amino acid acting at NMDA receptors; less active than the L-isomer.

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

Isomeric SMILES: C(CC(=O)O)[C@H](C(=O)O)N  
InChIKey: WHUUTDBJXJRKMK-GSVOUGTGSA-N  
InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1  

6893-26-1 Relevant articles

Electrochemical synthesis of (poly) dimethoxyaniline on glassy carbon electrodes and their applications in the detection of L-and D-glutamic acids

Xin Zeng1,2, Nan Li3,1 and Jichang Wang3,2

Journal of The Electrochemical Society, Volume 166, Number 9

Using cyclic voltammetry method, the anodic peak currents were found to have a linear relationship with the concentration of glutamic acids within the range between 0.5 and 15.0 mM, with a detection limit of 0.11 mM for L-glutamic acid and 0.26 mM for D-glutamic acid. The device-to-device reproducibility is great, confirming the robustness of this modification method.

Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis

Author links open overlay panelHuai Huang a b, Li-Ying Shi c, Li-Liang Wei d, Yu-Shuai Han b, Wen-Jing Yi b, Zhi-Wen Pan e, Ting-Ting Jiang a, Jing Chen b, Hui-Hui Tu b, Zhi-Bin Li b, Yu-Ting Hu a b, Ji-Cheng Li a b

Clinica Chimica Acta Volume 498, November 2019, Pages 135-142

The results suggested that Xanthine, 4-Pyridoxate, and d-glutamic acid may serve as potential biomarkers for pulmonary TB. The present study provides experimental basis for …

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

Zhang, Danping,Jing, Xiaoran,Zhang, Wenli,Nie, Yao,Xu, Yan

, p. 29927 - 29935 (2019/10/01)

d-Amino acids are key intermediates requ...

Artificial Biocatalytic Cascade with Three Enzymes in One Pot for Asymmetric Synthesis of Chiral Unnatural Amino Acids

Zhou, Haisheng,Meng, Lijun,Yin, Xinjian,Liu, Yayun,Xu, Gang,Wu, Jianping,Wu, Mianbin,Yang, Lirong

, p. 6470 - 6477 (2019/11/02)

Two biocatalytic reactions, transaminati...

6893-26-1 Process route

D-glutamic acid γ-p-nitroanilide
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D-glutamic acid γ-p-nitroanilide

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6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

D-Glutamic acid

4-nitro-aniline
100-01-6,104810-17-5

4-nitro-aniline

Conditions
Conditions Yield
With marine bivalve lysozyme; MOPS buffer; Tapes japonica; at 37 ℃; pH=7.0; Enzyme kinetics;
 
α-ketoglutaric acid
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α-ketoglutaric acid

D-norvaline
2013-12-9,498-18-0

D-norvaline

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D-Glutamic acid

2-oxopentanoic acid
1821-02-9

2-oxopentanoic acid

Conditions
Conditions Yield
With pyridoxal 5'-phosphate; recombinant Lactobacillus salivarius UCC118 D-amino acid aminotransferase; In aq. phosphate buffer; at 30 ℃; for 0.0166667h; pH=7.5; Enzymatic reaction;
 

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