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19764-30-8

  • Product NameN-Acetyl-D-Leucine
  • Molecular FormulaC8H15NO3
  • Molecular Weight173.212
  • Purity99%
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  • CasNo： 19764-30-8
  • Molecular Formula： C8H15NO3
  • Purity： 99%

Offer N-Acetyl-D-Leucine 19764-30-8 Best Price

  • Molecular Formula:C8H15NO3
  • Molecular Weight:173.212
  • Melting Point:176-177 °C 
  • Refractive Index:23 ° (C=4, EtOH) 
  • Boiling Point:369.7 °C at 760 mmHg 
  • PKA:3.67±0.10(Predicted) 
  • Flash Point:177.4 °C 
  • PSA：66.40000 
  • Density:1.069 g/cm3 
  • LogP:1.01270 

N-Acetyl-D-leucine(Cas 19764-30-8) Usage

Chemical Properties

White to off-white powder
Uses N-Acetyl-D-leucine is a metabolite found in or produced by Saccharomyces cerevisiae. It is used to help differentiate members of the amidohydrolase enzyme superfamily.

N-acetyl-D-leucine is the N-acetyl derivative of D-leucine. It is a N-acetyl-D-amino acid and a D-leucine derivative.

Isomeric SMILES: CC(C)C[C@H](C(=O)O)NC(=O)C  
InChIKey: WXNXCEHXYPACJF-SSDOTTSWSA-N  
InChI: InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m1/s1  

19764-30-8 Relevant articles

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

Grant C. Churchill ,Michael Strupp,Antony Galione,Frances M. Platt

Plos one, 2020

Although the N-acetyl-D-leucine is not reported to be toxic, concerns about the toxicity of D-amino acids in general have been raised as the reason for the original evolutionary selection and biological presence of D-amino acid oxidase.

Acetylation turns leucine into a drug by membrane transporter switching

Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt & Antony Galione

Scientific Reports volume 11, Article number: 15812 (2021)

Moreover, our recent findings that the enantiomers of N-acetyl-leucine (N-acetyl-L-leucine and N-acetyl-D-leucine) show unexpected and large differences in pharmacokinetics suggesting the involvement of differential binding sites provided by enzymes and transporters...

19764-30-8 Process route

(R)-leucine
328-38-1,21675-61-6,25248-98-0,70-45-1

(R)-leucine

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

4-nitro-phenol
100-02-7,78813-13-5,89830-32-0

4-nitro-phenol

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
Conditions Yield
β‐cyclodextrin; In water; dimethyl sulfoxide; at 25 ℃; Rate constant; Mechanism; various conditions;
 
N-acetylleucine
99-15-0

N-acetylleucine

L-leucine
61-90-5,21675-61-6,25248-98-0,70-45-1

L-leucine

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
Conditions Yield
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I; at 40 ℃; relative initial rate of hydrolysis;
 
With polymer-supported Thermococcus litoralis L-aminoacylase; at 20 ℃; pH=8; stereoselective reaction; aq. buffer; Enzymatic reaction;
 

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19764-30-8 Downstream products

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    (+)-(3R)-3-(N-acetyl-D-leucylamino)-3-benzyl-1-hydroxysuccinimide

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