What is the N-Acetyl-L-leucine?

N-Acetyl-L-leucine is white crystalline powder, while it's Molecular Formula is C8H15NO3. white crystalline powder N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

What is the CAS number for N-Acetyl-L-leucine?

The CAS number of N-Acetyl-L-leucine is 1188-21-2.

What is the N-Acetyl-L-leucine?

N-Acetyl-L-leucine is white crystalline powder, while it's Molecular Formula is C8H15NO3. white crystalline powder N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

What is the CAS number for N-Acetyl-L-leucine?

The CAS number of N-Acetyl-L-leucine is 1188-21-2.

High Purity N-Acetyl-L-Leucine 1188-21-2 In Medicine

Product Details

Quick Details

CasNo： 1188-21-2
Molecular Formula： C₈H₁₅NO₃
Appearance： white crystalline powder
Purity： 99%

High Purity N-Acetyl-L-Leucine 1188-21-2 In Medicine

Molecular Formula:C8H15NO3
Molecular Weight:173.212
Appearance/Colour:white crystalline powder
Vapor Pressure:1.77E-06mmHg at 25°C
Melting Point:187-190 °C(lit.)
Refractive Index:-22 ° (C=5, EtOH)
Boiling Point:369.7 °C at 760mmHg
PKA:3.67±0.10(Predicted)
Flash Point:177.4 °C
PSA：66.40000
Density:1.069 g/cm³
LogP:1.01270

N-Acetyl-L-leucine(Cas 1188-21-2) Usage

Chemical Properties	White crystalline powder
Uses	N-Acetyl-L-Leucine is an acetylated derivative of the essential amino acid leucine. It has a role as a metabolite. N-Acetyl-L-(-)-leucine (NALL) is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo. NALL can be used as a symptomatic treatment for NPC.
Definition	ChEBI: The N-acetyl derivative of L-leucine.
European Community (EC) Number	214-706-3
NSC Number	758152
UNII	E915HL7K2O
DSSTox Substance ID	DTXSID6045870

InChI:InChI=1/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/p-1/t7-/m0/s1

1188-21-2 Relevant articles

Efficacy and safety of N-acetyl-l-leucine in Niemann–Pick disease type C

Tatiana Bremova-Ertl, Jens Claassen, Tomas Foltan, Jordi Gascon-Bayarri, Paul Gissen, Andreas Hahn, Anhar Hassan, Anita Hennig, Simon A. Jones, Miriam Kolnikova, Kyriakos Martakis, Jan Raethjen, Uma Ramaswami, Reena Sharma & Susanne A. Schneider

Journal of Neurology volume 269, pages1651–1662 (2022)

Objective To investigate the safety and efficacy of N-acetyl-l-leucine (NALL) on symptoms, functioning, and quality of life in pediatric (≥ 6 years) and adult Niemann–Pick disease type C …

Efficacy and Safety of N-Acetyl-L-Leucine in Children and Adults With GM2 Gangliosidoses

Kyriakos Martakis, Jens Claassen, Jordi Gascon-Bayari, Nicolina Goldschagg, Andreas Hahn, Anhar Hassan, Anita Hennig, Simon Jones, Richard Kay, Heather Lau, Susan Perlman, Reena Sharma, Susanne Schneider, Tatiana Bremova-Ertl

Neurology, 2023

This clinical trial investigated N-acetyl-l-leucine (NALL), an orally administered, modified amino acid in pediatric (≥6 years) and adult patients with GM2 gangliosidoses. …

1188-21-2 Process route

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 830-03-5
4-nitrophenol acetate

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
β‐cyclodextrin; In water; dimethyl sulfoxide; at 25 ℃; Rate constant; Mechanism; various conditions;

: 244250-56-4
(S)-benzyl 2-acetamido-4-methylpentanoate

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 3h;	81%
With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 3h;	81%