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Product Details
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Description |
Boc-beta-Ala-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. |
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Chemical Properties |
White solid |
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Uses |
Boc-beta-alanine can be used as a PROTAC linker in the synthesis of PROTACs. |
InChI:InChI=1/C8H15NO4/c1-8(2,3)13-7(12)9-5-4-6(10)11/h4-5H2,1-3H3,(H,9,12)(H,10,11)/p-1
… study involved the condensation of BOC-beta-alanine with the bifunctional alkylating agent melphalan. The melphalan and BOC-beta-alanine were purchased from Sigma Chemical …
Then Masamune-Claisen beta keto ester 2 was assembled in one pot through the reaction of N- t Boc beta-alanine with Meldrum’s acid and further the intermediate formed in situ was …
Alternatively, the Boc-β-Fr-OMe dimer (22) can be synthesized from 1 by coupling to the symmetrical anhydride of Boc-beta-alanine in DMF, DIEA, and DMAP. The anhydride was pre-…
di-tert-butyl dicarbonate
3-amino propanoic acid
3-(tert-butyloxycarbonylamino)propionic acid
| Conditions | Yield |
|---|---|
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With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃;
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100% |
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With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃;
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100% |
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With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
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100% |
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With sodium hydroxide; In methanol; at 0 - 20 ℃;
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99% |
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With potassium carbonate; In 1,4-dioxane; water;
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98% |
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With sodium hydroxide; In 1,4-dioxane; water; at 0 - 25 ℃; for 0.5h;
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98% |
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With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 16h;
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97% |
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With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;
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97% |
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With potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 24h;
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96% |
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With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;
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95% |
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With sodium hydroxide; In methanol; chloroform; at 20 ℃; for 3h;
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94.17% |
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With sodium hydroxide; at 20 ℃; for 20h;
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94% |
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With sodium hydroxide; at 20 ℃; for 20h;
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94% |
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With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 6h;
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92% |
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With sodium hydroxide; In 1,4-dioxane; at 20 ℃;
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91% |
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With sodium hydroxide; In water; tert-butyl alcohol; for 12h; Ambient temperature;
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90% |
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With sodium hydroxide; at 0 - 20 ℃; for 3h;
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90% |
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With sodium hydroxide; In 1,4-dioxane; 0 deg C to room temp.,;
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88% |
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With sodium hydroxide; In 1,4-dioxane; water; at 30 ℃; for 6h;
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88.85% |
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With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃;
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88% |
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With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 0.5h;
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87% |
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With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
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87% |
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With sodium hydroxide; In water; tert-butyl alcohol; at 20 - 40 ℃; for 16h;
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86% |
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With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h;
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85% |
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3-amino propanoic acid; With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃; for 0.0833333h;
di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
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82% |
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With sodium hydroxide; Ambient temperature;
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80% |
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With sodium hydroxide; In 1,4-dioxane; at 0 - 30 ℃; for 16h;
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80% |
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With sodium hydroxide; In tetrahydrofuran; water; at 5 - 20 ℃; for 12h;
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80% |
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With sodium hydroxide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
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80% |
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With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 12h;
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79% |
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With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
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76% |
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With sodium hydroxide; tert-butyl alcohol; In water; at 30 ℃; for 18h;
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73% |
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With dmap; In dichloromethane; at 0 - 20 ℃;
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70% |
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With dmap; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
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70% |
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With potassium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 12h;
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68% |
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With sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃; for 16h; Inert atmosphere;
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56% |
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With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h;
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51% |
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With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
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51% |
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With sodium hydroxide; In isopropyl alcohol; at 0 - 20 ℃; for 2h;
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50% |
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With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 16h; Inert atmosphere;
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8% |
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With potassium carbonate; In 1,4-dioxane; water; for 2.5h; Ambient temperature;
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With sodium hydroxide; In tert-butyl alcohol; for 12h;
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With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃;
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With sodium hydroxide;
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In sodium hydrogencarbonate; ethyl acetate; acetonitrile;
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3.71 g (98%) |
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With sodium hydroxide; In water;
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With sodium hydrogencarbonate; In 1,4-dioxane; water; Cooling with ice;
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di-tert-butyl dicarbonate; 3-amino propanoic acid; With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h;
With sodium hydrogen sulfate; In water; ethyl acetate;
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With potassium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
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With sodium hydroxide; In 1,4-dioxane; water;
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With water; sodium hydroxide; In tert-butyl alcohol;
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di-tert-butyl dicarbonate; 3-amino propanoic acid; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 6h; pH=9 - 11;
With citric acid; In water; pH=4 - 5;
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With sodium hydroxide; In tert-butyl alcohol; at 20 ℃;
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With sodium hydroxide; at 20 ℃; for 3h;
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With water; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
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With sodium hydroxide; In 1,4-dioxane; at 20 ℃;
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With potassium hydroxide; In 1,4-dioxane; water; at 25 ℃; for 12h;
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With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
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With sodium hydroxide; In aq. phosphate buffer;
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1.89 g |
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di-tert-butyl dicarbonate; 3-amino propanoic acid; With sodium hydroxide; In water; at 20 ℃; for 12h;
With hydrogenchloride; In water;
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With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 16h;
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With sodium carbonate; In tetrahydrofuran; water; Inert atmosphere;
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With sodium hydroxide; In isopropyl alcohol; at 0 - 20 ℃; for 2h;
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With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 18h;
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1.26 g |
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With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 16.0833h; Inert atmosphere;
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With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 25h;
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With sodium hydroxide; In water; tert-butyl alcohol; at 0 - 20 ℃;
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With sodium hydroxide; In tert-butyl alcohol; at 20 ℃;
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With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 8h;
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di-tert-butyl dicarbonate; 3-amino propanoic acid; With sodium hydroxide; for 0.333333h; Cooling with ice;
In water; at 20 ℃; for 14h; Further stages;
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3.39 g |
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With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 3h;
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In tetrahydrofuran; water; for 18h; Reflux;
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With triethylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃; Sonication;
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With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 3h; Inert atmosphere;
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3-tert-butoxycarbonylamino-propionic acid ethyl ester
3-(tert-butyloxycarbonylamino)propionic acid
| Conditions | Yield |
|---|---|
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With water; lithium hydroxide; In ethanol; at 20 ℃; for 5h;
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90% |
succinic acid anhydride
tert-butyl alcohol
t-butylpentachlorophenyl carbonate
sodium β-alaninate
2,4-Dinitrophenylester von BOC-β-Alanin
2,4,5-trichlorophenyl 3-<(tert-butyloxycarbonyl)amino>propanoate
Boc-β-Ala-L-Trp-L-Leu-L-Asn-OBzl
Boc-β-Ala-L-Trp-L-Nle-L-Asp(Bzl)-NH2
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