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149-87-1

  • Product NameDL-Pyroglutamic acid
  • Molecular FormulaC5H7NO3
  • Molecular Weight129.115
  • Purity99%
  • Appearancewhite crystalline powder
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  • CasNo： 149-87-1
  • Molecular Formula： C5H7NO3
  • Appearance： white crystalline powder
  • Purity： 99%

Sale High Purity DL-Pyroglutamic Acid 149-87-1

  • Molecular Formula:C5H7NO3
  • Molecular Weight:129.115
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:1.79E-09mmHg at 25°C 
  • Melting Point:183-185 °C(lit.) 
  • Refractive Index:1.511 
  • Boiling Point:453.1 °C at 760 mmHg 
  • PKA:3.48±0.20(Predicted) 
  • Flash Point:227.8 °C 
  • PSA：66.40000 
  • Density:1.38 g/cm3 
  • LogP:-0.32160 

DL-Pyroglutamic acid(Cas 149-87-1) Usage

Chemical Properties

white crystalline powder

Uses

DL-pyroglutamic acid (PCA) is used in the preparation of AZT steroid conjugates as potent anti-HIV agents. DL-pyroglutamic acid can be used as a novel heterogeneous catalyst for Suzuki–Miyaura coupling reactions.

Definition

ChEBI: An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1

149-87-1 Relevant articles

Degradation kinetics of L-glutamine in aqueous solution

Arii, Kanji,Kobayashi, Hideyuki,Kai, Toshiya,Kokuba, Yukifumi

, p. 75 - 78 (1999)

The degradation kinetics of L-glutamine ...

Terahertz spectroscopy of enantiomeric and racemic pyroglutamic acid

Zhipeng Wu , Zhongjie Zhu , Chao Cheng , Jianbing Zhang , Yan Gong , Mingzhu Xu , Shaoping Li , Hongwei Zhao

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume 225, 15 January 2020, 117509

The low-frequency vibrational properties of D-, L- and DL-pyroglutamic acid (PGA) have been investigated with the terahertz time-domain spectroscopy (THz-TDS) from 0.5 to 4.5 THz. …

Antidepressant and antinociceptive activities in animal models and in vitro assessment of the anti-thyroid activity of bis (DL-pyroglutamate) magnesium complex

Nancy Martini , Juliana E. Parente , Maria Eugenia Toledo , Graciela E. Escudero , Carlos H. Laino , Oscar E. Piro , Gustavo A. Echeverría , Patricia A.M. Williams , Evelina G. Ferrer

Pharmacological Reports Volume 71, Issue 6, December 2019, Pages 1273-1280

In this work we demonstrated that the presence of the racemic DL-Pyroglutamic acid favors crystallization of [Mg(DL-pGlu) 2 ] complex. We obtained promising results (i) antidepressant …

149-87-1 Process route

phthalic anhydride
85-44-9

phthalic anhydride

L-glutamine
56-85-9,26700-71-0

L-glutamine

thalidomide
50-35-1

thalidomide

Pyroglutamic acid
149-87-1

Pyroglutamic acid

Conditions
Conditions Yield
for 0.316667h; Microwave irradiation;
 
α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

Glutamic acid
617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

Glutamic acid

Pyroglutamic acid
149-87-1

Pyroglutamic acid

Conditions
Conditions Yield
With phenylglycin; In water; acetonitrile; for 24h; Inert atmosphere; Reflux;
19 %Spectr.
31 %Spectr.

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