5680-79-5

  • Product NameGlycine methyl ester hydrochloride
  • Molecular FormulaC3H8ClNO2
  • Molecular Weight125.555
  • Purity99%
  • AppearanceCrystalline
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Product Details

Quick Details

  • CasNo: 5680-79-5
  • Molecular Formula: C3H8ClNO2
  • Appearance: Crystalline
  • Purity: 99%

Glycine methyl ester hydrochloride 5680-79-5 Powder

  • Molecular Formula:C3H8ClNO2
  • Molecular Weight:125.555
  • Appearance/Colour:Crystalline 
  • Vapor Pressure:79.8mmHg at 25°C 
  • Melting Point:175 °C (dec.)(lit.) 
  • Boiling Point:82.1 °C at 760 mmHg 
  • PSA:52.32000 
  • Density:1.000 
  • LogP:0.62040 

Glycine methyl ester hydrochloride(Cas 5680-79-5) Usage

Chemical Properties

Crystalline

Uses

A Glycine ester, a non-essential amino acid for human development.

Purification Methods

Crystallise the ester salt from MeOH. [Werbin & Spoerri J Am Chem Soc 69 1682 1947, Beilstein 4 H 340, 4 III 1116.]

InChI:InChI=1/C3H7NO2/c1-6-3(5)2-4/h2,4H2,1H3/p+1

5680-79-5 Relevant articles

Synthesis of N-(imidomethyl)glycine esters from alkyl glycinates, imides of dicarboxylic acids, and formaldehyde

Zlotin, S. G.,Sharova, I. V.,Luk'yanov, O. A.

, p. 1260 - 1261 (1995)

A method for preparing N-(imidomethyl)gl...

Optimizing delivery of flurbiprofen to the colon using a targeted prodrug approach

Philip, Anil K.,Dubey, Rajesh K.,Pathak, Kamla

, p. 607 - 613 (2008)

The carboxylic group responsible for the...

Glycine modified graphene oxide as a novel sorbent for preconcentration of chromium, copper, and zinc ions from water samples prior to energy dispersive X-ray fluorescence spectrometric determination

Pytlakowska, Katarzyna,Kozik, Violetta,Matussek, Marek,Pilch, Micha?,Hachu?a, Barbara,Kocot, Karina

, p. 42836 - 42844 (2016)

A novel and selective sorbent for micro-...

Microwave-Assisted Ruthenium- and Rhodium-Catalyzed Couplings of α-Amino Acid Ester-Derived Phosphinamides with Alkynes

Gong, Jun-Fang,Li, Xue-Hong,Song, Mao-Ping

supporting information, (2021/12/23)

Two different types of new phosphinamide...

Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor**

Sardar, Avijit,Lahiri, Aritraa,Kamble, Mithila,Mallick, Amirul I.,Tarafdar, Pradip K.

supporting information, p. 6101 - 6106 (2021/02/01)

The entry of enveloped virus requires th...

Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis

Guo, Peng,Wang, Ke,Jin, Wen-Jie,Xie, Hao,Qi, Liangliang,Liu, Xue-Yuan,Shu, Xing-Zhong

supporting information, p. 513 - 523 (2021/01/12)

Catalytic transformation of alcohols via...

Silver-Mediated [3 + 2] Cycloaddition of Azomethine Ylides with Trifluoroacetimidoyl Chlorides for the Synthesis of 5-(Trifluoromethyl)imidazoles

Yang, Hefei,Lu, Shu-Ning,Chen, Zhengkai,Wu, Xiao-Feng

supporting information, p. 4361 - 4370 (2021/03/09)

A silver-mediated [3 + 2] cycloaddition ...

5680-79-5 Process route

methanol
67-56-1

methanol

glycine
56-40-6,18875-39-3,25718-94-9

glycine

glycine ethyl ester hydrochloride
5680-79-5,883886-67-7

glycine ethyl ester hydrochloride

Conditions
Conditions Yield
With acetyl chloride; at 0 - 20 ℃;
100%
methanol; With thionyl chloride; for 1h; Cooling with ice;
glycine; at 20 - 66 ℃; for 6.5h;
100%
With thionyl chloride; at 0 ℃; Reflux; Inert atmosphere;
100%
With thionyl chloride; at 0 - 20 ℃;
100%
glycine; With chloro-trimethyl-silane; at 20 ℃; for 0.166667h;
methanol; at 20 ℃; for 48h;
100%
With thionyl chloride; for 3h; Reflux;
100%
With thionyl chloride; at -5 - 80 ℃; for 3h;
100%
With thionyl chloride; at 25 - 30 ℃; for 0.5h; microwave irradiation;
99%
With thionyl chloride; at -5 - 20 ℃; for 3h; Inert atmosphere;
99%
With thionyl chloride; at 40 ℃; for 2h;
98%
With thionyl chloride; Heating;
98%
With thionyl chloride; at -5 - 20 ℃;
98%
With thionyl chloride; at 0 - 20 ℃; for 6h;
98%
With thionyl chloride; for 8h; Heating;
97%
With thionyl chloride; for 8h; Reflux;
97%
With thionyl chloride; at 0 - 20 ℃;
97%
With chloro-trimethyl-silane; at 20 ℃; for 24h;
96%
With thionyl chloride; at 20 ℃; Inert atmosphere;
96%
With thionyl chloride; at 0 - 20 ℃;
96%
With thionyl chloride; at 0 - 60 ℃; for 4h;
95%
With hydrogenchloride; at 20 - 100 ℃; for 3.08333h; Temperature;
95.64%
With hydrogenchloride; In water; at 40 - 60 ℃; Large scale;
95.28%
With hydrogenchloride; at 20 ℃; for 18h;
94%
With acetyl chloride; at 0 ℃; for 3h; Reflux;
92%
With thionyl chloride; at 16 - 20 ℃; for 48h;
91.5%
With chloro-trimethyl-silane; at 20 ℃; for 24h; Sealed tube;
90%
With chloro-trimethyl-silane; at 20 ℃; for 24h; Sealed tube;
90%
With hydrogenchloride; for 2h; Reflux;
90%
methanol; With acetyl chloride; at -5 - 5 ℃; for 1h;
glycine; at 70 ℃; for 5h;
90.68%
With thionyl chloride; at 0 ℃; Reflux;
90%
With thionyl chloride; at 0 - 20 ℃;
89%
With thionyl chloride;
89%
With thionyl chloride; In methanol; for 0.5h; Heating;
88%
With thionyl chloride; at 0 ℃; Reflux;
88%
With thionyl chloride; at -5 ℃; for 7h; Reflux;
88%
With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;
84%
With thionyl chloride; at 0 - 20 ℃; for 16h;
81%
With thionyl chloride; 7 h, 0-5 deg C; 12 h, 10 deg C; 10 h, 40 deg C;
80%
With hydrogenchloride; Inert atmosphere;
80%
With thionyl chloride; at 0 - 20 ℃;
80%
With hydrogenchloride; at 0 ℃;
80%
With thionyl chloride; at 40 ℃; for 2h;
73%
With thionyl chloride; for 2h; Heating;
With thionyl chloride; Ambient temperature;
With thionyl chloride; Heating;
With thionyl chloride; for 6h; Ambient temperature;
With thionyl chloride; for 1h; Heating;
With hydrogenchloride; 3 A molecular sieve; for 2.5h; Heating;
With thionyl chloride; Yield given; 1) RT, 30 min, 2) 40 deg C, 2 h;
With hydrogenchloride; for 4h; Yield given; Heating;
With thionyl chloride; for 24h; Yield given; Ambient temperature;
With thionyl chloride;
With hydrogenchloride;
With thionyl chloride;
methanol; With thionyl chloride; at 0 ℃; for 0.5h;
glycine; Heating;
With thionyl chloride; for 6h;
With hydrogenchloride; for 2h; Heating / reflux;
With sulfuryl dichloride; at 0 ℃;
With thionyl chloride; at 60 - 70 ℃; for 10h; Heating;
With thionyl chloride;
With thionyl chloride;
With hydrogenchloride;
With thionyl chloride; at 20 ℃;
With thionyl chloride; at 0 ℃; Reflux;
With hydrogenchloride;
With thionyl chloride; at 78 ℃;
With thionyl chloride; at 60 - 70 ℃;
With acetyl chloride; Reflux;
With thionyl chloride; at 55 ℃; for 6h;
With thionyl chloride;
With thionyl chloride; at 5 ℃; Inert atmosphere; Reflux;
With thionyl chloride; In methanol; Reflux;
With thionyl chloride;
With thionyl chloride; at 78 ℃;
With thionyl chloride; at 0 ℃; for 1.5h; Inert atmosphere; Reflux;
With thionyl chloride; at -5 - 20 ℃;
With thionyl chloride; Inert atmosphere; Reflux;
With thionyl chloride;
methanol; With thionyl chloride; at 0 ℃; for 1h;
glycine; at 90 ℃; for 15h;
With thionyl chloride;
With thionyl chloride;
methanol; With thionyl chloride; In methanol; at 0 - 20 ℃; for 2.5h;
glycine; In methanol; for 4h; Reflux;
methanol; With thionyl chloride; at 0 - 20 ℃;
glycine; for 4h; Reflux;
With thionyl chloride;
With thionyl chloride; at 0 ℃; for 4h; Reflux;
1.253 g
methanol; glycine; With thionyl chloride; at 0 ℃;
Heating;
With thionyl chloride; at 0 - 20 ℃; for 16h; Inert atmosphere;
With thionyl chloride; at 0 ℃; Reflux;
With thionyl chloride; at 60 ℃; Cooling with ice;
With hydrogenchloride; at 65 - 70 ℃; for 1.25h;
4.93 g
With thionyl chloride;
With thionyl chloride; at 20 ℃; Cooling with ice;
With thionyl chloride; at 0 - 20 ℃;
With thionyl chloride; at -5 - 20 ℃; for 3h; Inert atmosphere;
With thionyl chloride; for 12h; Reflux;
glycine; With chloro-trimethyl-silane; at 20 ℃; for 0.333333h;
methanol; at 20 ℃; for 24h;
With thionyl chloride; at 0 ℃;
With thionyl chloride; at 0 ℃; Reflux; Inert atmosphere; Sealed tube;
With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;
With thionyl chloride; at -10 - 20 ℃; for 0.6h;
With thionyl chloride; at 0 - 65 ℃; for 8h; Inert atmosphere;
16.57 g
methoxycarbonylmethylamine
616-34-2

methoxycarbonylmethylamine

glycine ethyl ester hydrochloride
5680-79-5,883886-67-7

glycine ethyl ester hydrochloride

Conditions
Conditions Yield
With thionyl chloride; In methanol; at -10 ℃; for 0.166667h;
99.5%

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