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  • Product Name(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride
  • Molecular FormulaC6H12ClNO2
  • Molecular Weight165.61798
  • Purity99%

Product Details

Quick Details

  • CasNo: 1508261-86-6
  • Molecular Formula: C6H12ClNO2
  • Purity: 99%

Pharmaceutical Intermediates (S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride 1508261-86-6 Best Price

  • Molecular Formula:C6H12ClNO2
  • Molecular Weight:165.61798
  • PSA:49.33000 
  • LogP:1.34390 

(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride(Cas 1508261-86-6) Usage

(S)-2-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride is commonly used as a chiral building block in the preparation of drugs such as antihypertensive agents, anticonvulsants, and antiviral agents.

IUPAC Name: (2S)-2-methylpyrrolidine-2-carboxylic acid;hydrochloride  
Isomeric SMILES: C[C@]1(CCCN1)C(=O)O.Cl  
InChI: InChI=1S/C6H11NO2.ClH/c1-6(5(8)9)3-2-4-7-6;/h7H,2-4H2,1H3,(H,8,9);1H/t6-;/m0./s1  

1508261-86-6 Relevant articles

New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine

Nana Wang 1,Haibo Mei 1,Gagan Dhawan 2,3,4,,Wei Zhang 5,,Jianlin Han 1, andVadim A. Soloshonok 6,7

, Molecules 2023, 28(9), 3651;

The synthesis of daridorexant is described in Scheme 7, using (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride as the starting material. First, one key triazole intermediate 49 is prepared via a Cu-catalyzed cross-coupling reaction of 2-iodo-5-methoxybenzoic acid and 2H-1,2,3-triazole. On the other hand, the amino group of (S)-2-methylpyrrolidine-2-carboxylic acid is protected by tert-butyloxy carbonyl (Boc) in the presence of trimethylamine.

Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R

Author links open overlay panelVattoly J. Majo a, Victoria Arango a b, Norman R. Simpson b, Jaya Prabhakaran a, Suham A. Kassir b, Mark D. Underwood a b, Mihran Bakalian b, Peter Canoll c, J. John Mann a b d, J.S. Dileep Kumar a b

, Bioorganic & Medicinal Chemistry Letters Volume 23, Issue 14, 15 July 2013, Pages 4191-4194

… 3-amine (5) followed by displacement at C-2 position with (S)-2-methylpyrrolidine-2-carboxylic acid gave the corresponding carboxylic acid 7 in two steps with 65% yield. The carboxylic …